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SENP1

SUMO1/sentrin specific peptidase 1

Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. Deconjugates SUMO1 from HIPK2. Deconjugates SUMO1 from HDAC1 and BHLHE40/DEC1, which decreases its transcriptional repression activity. Deconjugates SUMO1 from CLOCK, which decreases its transcriptional activation activity. Deconjugates SUMO2 from MTA1.

Gene Name: SUMO1/sentrin specific peptidase 1
Family/Subfamily: Protease , Cysteine C48
Synonyms: SENP1, Sentrin-specific protease 1, SuPr-2
Target Sequences: NM_014554 NP_055369.1 Q9P0U3

Publications (1)

1
MDM2-ARF complex regulates p53 sumoylation. Chen L, Chen J. Oncogene. 2003 22:5348-57. [PubMed:12917636] Related Antibodies: LS-B3387.

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).