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SEMA3A / Semaphorin 3A

sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A

SEMA3A / Semaphorin 3A is a member of the semaphorin family and encodes a protein with an Ig-like C2-type (immunoglobulin-like) domain, a PSI domain and a Sema domain. This secreted protein can function as either a chemorepulsive agent, inhibiting axonal outgrowth, or as a chemoattractive agent, stimulating the growth of apical dendrites. In both cases, the protein is vital for normal neuronal pattern development. Increased expression of this protein is associated with schizophrenia and is seen in a variety of human tumor cell lines. Also, aberrant release of this protein is associated with the progression of Alzheimer's disease.

Gene Name: sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
Synonyms: SEMA3A, Collapsin 1, Coll-1, Hsema-III, Hsema-I, Sema III, SEMAIII, SEMAL, Semaphorin III, Semaphorin-3A, Semaphorin-iii (hsema-i), SemD, SEMA1, Semaphorin D, COLL1, SEMAD, Semaphorin 3A, Semaphorin L, SEM3A
Target Sequences: NM_006080 NP_006071.1 Q14563

Publications (1)

1
Myeloid-resident neuropilin-1 promotes choroidal neovascularization while mitigating inflammation. Elisabeth M M A Andriessen, François Binet , Frédérik Fournier, Masayuki Hata, Agnieszka Dejda, Gaëlle Mawambo, Sergio Crespo-Garcia , Frédérique Pilon, Manuel Buscarlet, Karine Beauchemin, Véronique Bougie, Garth Cumberlidge, Ariel M Wilson, Steve Bourgault, Flavio A Rezende, Normand Beaulieu, Jean-Sébastien Delisle, Przemyslaw Sapieha. EMBO molecular medicine. 2021 May;13:e11754. [Full Text Article] [PubMed:33876574] [PMC:PMC8103107]

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).