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SELS
VCP-interacting membrane protein
This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Studies suggest that this protein may regulate cytokine production, and thus play a key role in the control of the inflammatory response. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.
| Gene Name: | VCP-interacting membrane protein |
| Synonyms: | VIMP, AD-015, ADO15, SEPS1, SBBI8, Selenoprotein S, SELS |
| Target Sequences: | NM_018445 NP_060915.2 Q9BQE4 |
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