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SEL1L

sel-1 suppressor of lin-12-like (C. elegans)

May play a role in Notch signaling (By similarity). May be involved in the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins.

Gene Name:	sel-1 suppressor of lin-12-like (C. elegans)
Synonyms:	SEL1L, PRO1063, Protein sel-1 homolog 1, SEL1L1, Sel-1L, TSA305, SEL1-LIKE, IBD2
Target Sequences:	NM_005065 NP_005056.3 Q9UBV2

Publications (2)

Human XTP3-B forms an endoplasmic reticulum quality control scaffold with the HRD1-SEL1L ubiquitin ligase complex and BiP. Nobuko Hosokawa, Ikuo Wada, Koji Nagasawa, Tatsuya Moriyama, Katsuya Okawa, Kazuhiro Nagata. The Journal of biological chemistry. 2008 July;283:20914-24. [Full Text Article] [PubMed:18502753] [PMC:PMC3258950]

Abnormal expression of ER quality control and ER associated degradation proteins in the dorsolateral prefrontal cortex in schizophrenia. Pitna Kim, Madeline R Scott, James H Meador-Woodruff. Schizophrenia research. 2018 Jul;197:484-491. [Full Text Article] [PubMed:29496332] [PMC:PMC6109614]

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