Securin / PTTG1

pituitary tumor-transforming 1

Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity and related apoptosis activity of TP53. The negative regulation of TP53 may explain the strong transforming capability of the protein when it is overexpressed. May also play a role in DNA repair via its interaction with Ku, possibly by connecting DNA damage-response pathways with sister chromatid separation.

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Proteins (8)

Type

Over-Expression Lysate (2)

Recombinant (6)

Target

Securin / PTTG1 (8)

Publications

No (8)

Tag

GST (1)

GST, N-terminus (1)

His (1)

His-T7 (2)

Myc-DDK (Flag) (3)

Species

Human (6)

Mouse (1)

Source

293T Cells (1)

E. coli (3)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (2)

Low Endotoxin Level

Low endotoxin level (1)

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Human Securin / PTTG1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G70054

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

21.8 kDa

Price:

20 µg/$1,107

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Human Securin / PTTG1 Protein (Recombinant GST, N-terminus) (aa1-100) - LS-G61044

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human Securin / PTTG1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G86162

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

21.8 kDa

Price:

20 µg/$150

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Human Securin / PTTG1 Protein (Recombinant His-T7) (aa2-202) - LS-G25070

Source:

E. coli

Tag:

His-T7

Molecular Weight:

25.6 kDa

Price:

10 µg/$268; 50 µg/$362; 100 µg/$577; 200 µg/$722; 1 mg/$1,755; 500 µg/$1,325; 5 mg/$2,708; 2 mg/$1,934

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Mouse Securin / PTTG1 Protein (Recombinant His-T7) (aa2-199) - LS-G25071

Source:

E. coli

Tag:

His-T7

Molecular Weight:

25.3 kDa

Price:

10 µg/$273; 50 µg/$392; 100 µg/$625; 200 µg/$782; 1 mg/$1,847; 500 µg/$1,404; 5 mg/$2,807; 2 mg/$2,029

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Human Securin / PTTG1 Protein (Recombinant GST) (Full Length) - LS-G31541

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

48.4 kDa

Price:

10 µg/$479; 25 µg/$670

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Securin / PTTG1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G116804

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

21.8 kDa

Price:

100 µg/$494

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Human Securin / PTTG1 Protein (Recombinant His) - LS-G586

Source:

E. coli

Tag:

His

Endotoxin Level:

Less than 0.5 EU/µg protein (determined by LAL method).

Price:

100 µg/$411; 500 µg/$985; 20 µg/$276

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