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SDHB

succinate dehydrogenase complex, subunit B, iron sulfur (Ip)

Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis.

Gene Name: succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
Synonyms: SDHB, SDH1, SDHIP, SDH, IP, PGL4, SDH2
Target Sequences: NM_003000 NP_002991.2 P21912

Publications (3)

1
Comparative Analysis of the APOL1 Variants in the Genetic Landscape of Renal Carcinoma Cells. Maty Tzukerman, Yeela Shamai, Ifat Abramovich, Eyal Gottlieb, Sara Selig, Karl Skorecki. Cancers. 2022 January;14:733. [Full Text Article] [PubMed:35159001] [PMC:PMC8833631] Related Antibodies: LS-C497529.
2
Endoplasmic reticulum-translocation is essential for APOL1 cellular toxicity. Etty Kruzel-Davila, Ira Bavli-Kertselli, Ayala Ofir, Amber M Cheatham, Revital Shemer, Eid Zaknoun, Sergiy Chornyy, Orly Tabachnikov, Shamara E Davis, Atanu K Khatua, Karl Skorecki, Waldemar Popik. iScience. 2022 January;25:103717. [Full Text Article] [PubMed:35072009] [PMC:PMC8762391] Related Antibodies: LS-C497529.
3
Rare and private variations in neural crest, apoptosis and sarcomere genes define the polygenic background of isolated Tetralogy of Fallot. Grunert M, Dorn C, Schueler M, Dunkel I, Schlesinger J, Mebus S, Alexi-Meskishvili V, Perrot A, Wassilew K, Timmermann B, Hetzer R, Berger F, Sperling SR. Human molecular genetics. 2014 Jun;23:3115-28. [Full Text Article] [PubMed:24459294] Related Antibodies: LS-B6428.

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Proteins (5)
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SDHB (5)
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SDHB Protein - Recombinant  Succinate Dehydrogenase Complex Subunit B By SDS-PAGE
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E. coli
His, N-Terminal
25 kDa
10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148
SDHB Protein
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E. coli
His, N-Terminal
31.6 kDa
50 µg/$419
SDHB Protein - 12.5% SDS-PAGE of human SDHB stained with Coomassie Blue
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Wheat Germ Extract
GST
58 kDa
2 µg/$439
SDHB Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
31.63 kDa
20 µg/$150
SDHB Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
31.63 kDa
100 µg/$494
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).