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SDHAF2

succinate dehydrogenase complex assembly factor 2

Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDHA of the SDH catalytic dimer.

Gene Name: succinate dehydrogenase complex assembly factor 2
Synonyms: SDHAF2, PGL2, SDH assembly factor 2, SDH5, C11orf79, HSDH5
Target Sequences: NM_017841 NP_060311.1 Q9NX18

Publications (1)

1
NLRP3 inflammasome deficiency attenuates metabolic disturbances involving alterations in the gut microbial profile in mice exposed to high fat diet. Marina Sokolova, Kuan Yang, Simen H Hansen, Mieke C Louwe, Martin Kummen, Johannes E R Hov, Ivar Sjaastad, Rolf K Berge, Bente Halvorsen, Pål Aukrust, Arne Yndestad, Trine Ranheim. Scientific reports. 2020 December;10:21006. [Full Text Article] [PubMed:33273482] [PMC:PMC7712828] Related Antibodies: LS-B9643.

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293T Cells
Myc-DDK (Flag)
19.4 kDa
20 µg/$150
SDHAF2 Protein - Purified recombinant protein SDHAF2 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
19.4 kDa
20 µg/$1,107
SDHAF2 Protein
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100 µg/$361; 500 µg/$739; 20 µg/$261
SDHAF2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
19.4 kDa
100 µg/$494
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).