SDF1 / CXCL12

chemokine (C-X-C motif) ligand 12

Chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. SDF-1-beta(3-72) and SDF-1-alpha(3-67) show a reduced chemotactic activity. Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha(3-67) and thus to preserve activity on local sites. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Inhibits CXCR4-mediated infection by T-cell line-adapted HIV-1. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of ACKR3 expressed in various cells. Has several critical functions during embryonic development; required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation.

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Products

Proteins (52)

Type

Over-Expression Lysate (2)

Recombinant (50)

Target

SDF1 / CXCL12 (52)

Application

Bind (1)

ELISA (1)

Func (1)

SDS-PAGE (5)

Format

Animal-free (2)

Publications

No (52)

Tag

GST (1)

His (3)

His, N-Terminal (1)

His,N-terminus (1)

His-GST (2)

His-GST, N-terminus (1)

Human IgG1 Fc, N-terminus (2)

Myc-DDK (Flag) (3)

Species

Human (32)

Mouse (14)

Rat (5)

Source

293T Cells (1)

CHO Cells (1)

E. coli (43)

HEK 293 Cells (4)

Wheat Germ Extract (1)

Purification

Purified (25)

Low Endotoxin Level

Low endotoxin level (29)

Biologically Active

Biologically active (26)

Animal-free

Animal-free (2)

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Mouse SDF1 / CXCL12 Protein (Recombinant) (Lys22-Lys89) - LS-G27012

Source:

CHO Cells

Tag:

None

Biological Activity:

Biologically active

Endotoxin Level:

Less than 0.2 EU/µg protein (determined by LAL method).

Molecular Weight:

8 kDa (SDS-PAGE)

Price:

5 µg/$304; 25 µg/$402

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Human SDF1 / CXCL12 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67035

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

9.9 kDa

Price:

20 µg/$1,107

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Human SDF1 / CXCL12 Protein (Recombinant) (Lys22-Lys89) - LS-G51076

Source:

E. coli

Tag:

None

Application:

SDS-PAGE

Molecular Weight:

The recombinant human CXCL12 consists of 68 amino acids and predicts a molecular mass of 8 kDa.

Price:

20 µg/$317; 1 mg/$2,333; 100 µg/$480

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Human SDF1 / CXCL12 Protein (Recombinant His,N-terminus) (Lys22-Lys89) - LS-G51075

Source:

E. coli

Tag:

His,N-terminus

Application:

SDS-PAGE

Molecular Weight:

The recombinant human CXCL12 consists of 84 amino acids and predicts a molecular mass of 10 kDa.

Price:

50 µg/$364; 500 µg/$1,452

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Human SDF1 / CXCL12 Protein (Recombinant Human IgG1 Fc, N-terminus) (Lys22-Met93) - LS-G47814

Source:

HEK 293 Cells

Tag:

Human IgG1 Fc, N-terminus

Application:

Bind ELISA Func SDS-PAGE

Biological Activity:

Biologically active

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

The recombinant human SDF1/Fc is a disulfide-linked homodimeric protein. The reduced monomer consists of 309 amino acids and predicts a molecular mass of 35.2 kDa. As a result of glycosylation, rhSDF1/Fc monomer is approximately 43 kDa in SDS-PAGE under reducing conditions.

Price:

50 µg/$364

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Human SDF1 / CXCL12 Protein (Recombinant) (Lys22-Met93) - LS-G47819

Source:

E. coli

Tag:

None

Application:

SDS-PAGE

Molecular Weight:

The recombinant human CXCL12 consists of 73 amino acids and predicts a molecular mass of 8.6 kDa. It migrates as an approximately 12 kDa band in SDS-PAGE under reducing conditions.

Price:

50 µg/$441; 1 mg/$3,117; 5 µg/$263

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Mouse SDF1 / CXCL12 Protein (Recombinant) (Lys22-Lys89) - LS-G51161

Source:

E. coli

Tag:

None

Application:

SDS-PAGE

Molecular Weight:

The recombinant mouse CXCL12 consists of 69 amino acids and predicts a molecular mass of 8.1 KDa. It migrates as an approximately 8 KDa band in SDS-PAGE under reducing conditions.

Price:

10 µg/$255; 1 mg/$2,613; 100 µg/$512

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Mouse SDF1 / CXCL12 Protein (Recombinant His) (aa22-89) - LS-G11610

Source:

E. coli

Tag:

His

Molecular Weight:

9.5 kDa

Price:

10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060

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Human SDF1 / CXCL12 Protein (Recombinant His-GST) (aa23-89) - LS-G11611

Source:

E. coli

Tag:

His-GST

Molecular Weight:

40.2 kDa

Price:

10 µg/$267; 50 µg/$352; 100 µg/$562; 200 µg/$702; 1 mg/$1,723; 500 µg/$1,298; 5 mg/$2,673; 2 mg/$1,900

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Rat SDF1 / CXCL12 Protein (Recombinant His-GST) (aa21-89) - LS-G11612

Source:

E. coli

Tag:

His-GST

Molecular Weight:

40.4 kDa

Price:

10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176

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Human SDF1 / CXCL12 Protein (Recombinant His) (aa23-89) - LS-G11602

Source:

E. coli

Tag:

His

Molecular Weight:

9.9 kDa

Price:

10 µg/$267; 50 µg/$352; 100 µg/$562; 200 µg/$702; 1 mg/$1,723; 500 µg/$1,298; 5 mg/$2,673; 2 mg/$1,900

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Human SDF1 / CXCL12 Protein (Recombinant GST) (Full Length) - LS-G30363

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

35.53 kDa

Price:

2 µg/$439

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Mouse SDF1 / CXCL12 Protein (Recombinant) - LS-G37846

Tag:

None

Biological Activity:

Biologically active

Molecular Weight:

7.9 kD

Price:

10 µg/$484

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Human SDF1 / CXCL12 Protein (Recombinant) (Ser19-Met93) - LS-G38657

Source:

E. coli

Tag:

None

Endotoxin Level:

Less than 0.1 EU/µg protein (determined by LAL method).

Molecular Weight:

8.79kD

Price:

10 µg/$321; 50 µg/$534; 500 µg/$1,353; 1 mg/$1,725

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Human SDF1 / CXCL12 Protein (Recombinant) (Lys22-Lys89) - LS-G38658

Source:

E. coli

Tag:

None

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

8.12kD

Price:

10 µg/$321; 50 µg/$534; 500 µg/$1,585; 1 mg/$2,157

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Human SDF1 / CXCL12 Protein (Recombinant) (Lys22-Met93) - LS-G38659

Source:

E. coli

Tag:

None

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

8.53kD

Price:

10 µg/$321; 50 µg/$534; 500 µg/$1,585; 1 mg/$2,157

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Mouse SDF1 / CXCL12 Protein (Recombinant) (Lys22-Lys89) - LS-G39139

Source:

E. coli

Tag:

None

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

8.1kD

Price:

10 µg/$288; 50 µg/$442; 500 µg/$1,585; 1 mg/$2,157

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Human SDF1 / CXCL12 Protein (Recombinant) - LS-G37728

Tag:

None

Molecular Weight:

8.0 kD

Price:

10 µg/$476

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Human SDF1 / CXCL12 Protein (Recombinant) - LS-G143826

Source:

E. coli

Tag:

None

Endotoxin Level:

Less than 0.1 EU/µg protein (determined by LAL method).

Molecular Weight:

8 kDa

Price:

50 µg/$677

Select

Human SDF1 / CXCL12 Protein (Recombinant) - LS-G137608

Source:

E. coli

Tag:

None

Biological Activity:

Biologically active

Endotoxin Level:

Less than 0.01 ng/µg (Less than 0.1 EU/µg) (determined by LAL method).

Molecular Weight:

The 68 amino acid recombinant protein has a predicted molecular mass of approximately 7963.4 Da. The DTT-reduced protein migrates at approximately 7kDa and the non-reduced protein migrates at approximately 9kDa by SDS-PAGE. The N-terminal amino acid is Ly

Price:

10 µg/$344; 25 µg/$459; 100 µg/$720; 500 µg/$1,779

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Mouse SDF1 / CXCL12 Protein (Recombinant) - LS-G137766

Source:

E. coli

Tag:

None

Biological Activity:

Biologically active

Endotoxin Level:

Less than 0.01 ng/µg (determined by LAL method).

Molecular Weight:

The 68 amino acid recombinant protein has a predicted molecular mass of approximately 7.9 kD. The DTT-reduced protein migrates at approximately 10 kD and the non-reduced protein migrates at approximately 12 kD by SDS-PAGE. The N-terminal amino acid is Lys

Price:

10 µg/$352; 25 µg/$459; 100 µg/$720

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Mouse SDF1 / CXCL12 Protein (Recombinant) - LS-G137788

Source:

E. coli

Tag:

None

Biological Activity:

Biologically active

Endotoxin Level:

Less than 0.01 ng/µg (determined by LAL method).

Molecular Weight:

The 72 amino acid recombinant protein has a predicted molecular mass of approximately 8.5 kD. The DTT-reduced and non-reduced protein migrate at approximately 11 and 14 kD by SDS-PAGE respectively. The N-terminal amino acid is Lysine.

Price:

10 µg/$352; 25 µg/$459; 100 µg/$731

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Human SDF1 / CXCL12 Protein (Recombinant) - LS-G137799

Source:

E. coli

Tag:

None

Biological Activity:

Biologically active

Endotoxin Level:

Less than 0.01 ng/µg (determined by LAL method).

Molecular Weight:

The 74 amino acid recombinant protein has a predicted molecular mass of approximately 8.8 kD. The DTT-reduced and non-reduced protein migrate at approximately 13 and 15 kD by SDS-PAGE respectively. The N-terminal amino acid is Ser.

Price:

10 µg/$344; 25 µg/$406

Select

Mouse SDF1 / CXCL12 Protein (Recombinant) (Lys22-Lys89) - LS-G139848

Source:

E. coli

Tag:

None

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

8.1 kDa

Price:

20 µg/$360; 100 µg/$728

Select

Human SDF1 / CXCL12 Protein (Recombinant Human IgG1 Fc, N-terminus) - LS-G134294

Source:

HEK 293 Cells

Tag:

Human IgG1 Fc, N-terminus

Endotoxin Level:

Less than 5.0 EU/mg protein (determined by LAL method).

Molecular Weight:

~35 kDa (SDS-PAGE)

Price:

50 µg/$428

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