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SCRIB / Scribble
scribbled planar cell polarity protein
Scaffold protein involved in different aspects of polarized cells differentiation regulating epithelial and neuronal morphogenesis. Most probably functions in the establishment of apico-basal cell polarity. May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium. May also function in cell migration and adhesion and hence regulate cell invasion through MAPK signaling. May play a role in exocytosis and in the targeting synaptic vesicles to synapses. Functions as an activator of Rac GTPase activity.
| Gene Name: | scribbled planar cell polarity protein |
| Synonyms: | SCRIB, CRIB1, KIAA0147, HScrib, Protein LAP4, LAP4, SCRB1, SCRIB1, Scribble, Vartul, Protein scribble homolog, Scribbled homolog (Drosophila) |
| Target Sequences: | NM_015356 NP_056171.3 Q14160 |
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