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SCP1 / SYCP1

synaptonemal complex protein 1

Major component of the transverse filaments of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase.

Gene Name:	synaptonemal complex protein 1
Synonyms:	SYCP1, Cancer/testis antigen 8, SCP-1, Synaptonemal complex protein 1, SCP1, CT8, HOM-TES-14
Target Sequences:	NM_003176 NP_003167.2 Q15431

Publications (13)

Heritable and stable gene knockdown in rats. Dann CT, Alvarado AL, Hammer RE, Garbers DL. Proceedings of the National Academy of Sciences of the United States of America. 2006 103:11246-51. (ICC; Rat) [PubMed:16844779] [PMC:PMC1544073]

Small ubiquitin-related modifier (SUMO)-1, SUMO-2/3 and SUMOylation are involved with centromeric heterochromatin of chromosomes 9 and 1 and proteins of the synaptonemal complex during meiosis in men. Brown PW, Hwang K, Schlegel PN, Morris PL. Human reproduction (Oxford, England). 2008 23:2850-7. (WB, IP; Human) [PubMed:18694876] [PMC:PMC2583944]

In vitro germ cell differentiation from cynomolgus monkey embryonic stem cells. Yamauchi K, Hasegawa K, Chuma S, Nakatsuji N, Suemori H. PloS one. 2009 4:e5338. (ICC; Primate) [PubMed:19399191] [PMC:PMC2671468]

Gtsf1/Cue110, a gene encoding a protein with two copies of a CHHC Zn-finger motif, is involved in spermatogenesis and retrotransposon suppression in murine testes. Yoshimura T, Toyoda S, Kuramochi-Miyagawa S, Miyazaki T, Miyazaki S, Tashiro F, Yamato E, Nakano T, Miyazaki J. Developmental biology. 2009 335:216-27. (IHC; Human) [PubMed:19735653]

HP1 links histone methylation marks to meiotic synapsis in mice. Takada Y, Naruse C, Costa Y, Shirakawa T, Tachibana M, Sharif J, Kezuka-Shiotani F, Kakiuchi D, Masumoto H, Shinkai Y, Ohbo K, Peters AH, Turner JM, Asano M, Koseki H. Development (Cambridge, England). 2011 138:4207-17. [PubMed:21896631]

In vitro production of fertile sperm from murine spermatogonial stem cell lines. Sato T, Katagiri K, Yokonishi T, Kubota Y, Inoue K, Ogonuki N, Matoba S, Ogura A, Ogawa T. Nature communications. 2011 2:472. (ICC, IHC; Mouse) [PubMed:21915114]

HORMAD1-dependent checkpoint/surveillance mechanism eliminates asynaptic oocytes. Kogo H, Tsutsumi M, Ohye T, Inagaki H, Abe T, Kurahashi H. Genes to cells : devoted to molecular & cellular mechanisms. 2012 17:439-54. (ICC, IHC; Mouse) [PubMed:22530760]

Targeted inactivation of nuclear interaction partner of ALK disrupts meiotic prophase. Illert AL, Kawaguchi H, Antinozzi C, Bassermann F, Quintanilla-Martinez L, von Klitzing C, Hiwatari M, Peschel C, de Rooij DG, Morris SW, Barchi M, Duyster J. Development (Cambridge, England). 2012 139:2523-34. (Mouse) [PubMed:22696294] [PMC:PMC3383228]

Synaptonemal complex components persist at centromeres and are required for homologous centromere pairing in mouse spermatocytes. Bisig CG, Guiraldelli MF, Kouznetsova A, Scherthan H, Hg C, Dawson DS, Pezza RJ. PLoS genetics. 2012 8:e1002701. (ICC; Mouse) [PubMed:22761579] [PMC:PMC3386160]

Testis tissue explantation cures spermatogenic failure in c-Kit ligand mutant mice. Sato T, Yokonishi T, Komeya M, Katagiri K, Kubota Y, Matoba S, Ogonuki N, Ogura A, Yoshida S, Ogawa T. Proceedings of the National Academy of Sciences of the United States of America. 2012 109:16934-8. (ICC, IHC; Mouse) [PubMed:22984182] [PMC:PMC3479468]

In vitro spermatogenesis using an organ culture technique. Yokonishi T, Sato T, Katagiri K, Ogawa T. Methods in molecular biology (Clifton, N.J.). 2013 927:479-88. [PubMed:22992938]

HORMAD2 is essential for synapsis surveillance during meiotic prophase via the recruitment of ATR activity. Kogo H, Tsutsumi M, Inagaki H, Ohye T, Kiyonari H, Kurahashi H. Genes to cells : devoted to molecular & cellular mechanisms. 2012 17:897-912. (ICC; Mouse) [PubMed:23039116]

Splicing mutation in Sbf1 causes nonsyndromic male infertility in the rat. Liška F, Chylíková B, JankÅ¯ M, Šeda O, Vernerová Z, Pravenec M, KÅ™en V. Reproduction (Cambridge, England). 2016 152:215-23. (IF; Mouse) [Full Text Article] [PubMed:27335132] Related Antibodies: LS-C2911.

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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