SCOP / PHLPP

PH domain and leucine rich repeat protein phosphatase 1

Protein phosphatase that mediates dephosphorylation of 'Ser-473' of AKT1, 'Ser-660' of PRKCB isoform beta-II and 'Ser-657' of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of AKT1 triggers apoptosis and suppression of tumor growth. Controls the phosphorylation of AKT2 and AKT3 more efficiently than that of AKT1. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. Inhibits cancer cell proliferation and may act as a tumor suppressor. May act as a negative regulator of K-Ras signaling in membrane rafts.

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Proteins (3)

Type

Over-Expression Lysate (2)

Recombinant (1)

Target

SCOP / PHLPP (3)

Publications

No (3)

Tag

Myc-DDK (Flag) (3)

Species

Human (2)

Source

293T Cells (1)

HEK 293 Cells (2)

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SCOP / PHLPP Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G103899

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

184.5 kDa

Price:

100 µg/$494

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Human SCOP / PHLPP Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67490

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

184.5 kDa

Price:

20 µg/$1,107

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Human SCOP / PHLPP Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G79977

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

184.5 kDa

Price:

20 µg/$150

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