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SCO2

SCO2 cytochrome c oxidase assembly protein

Cytochrome c oxidase (COX) catalyzes the transfer of electrons from cytochrome c to molecular oxygen, which helps to maintain the proton gradient across the inner mitochondrial membrane that is necessary for aerobic ATP production. Human COX is a multimeric protein complex that requires several assembly factors; this gene encodes one of the COX assembly factors. The encoded protein is a metallochaperone that is involved in the biogenesis of cytochrome c oxidase subunit II. Mutations in this gene are associated with fatal infantile encephalocardiomyopathy and myopia 6.

Gene Name: SCO2 cytochrome c oxidase assembly protein
Synonyms: SCO2, SCO1L
Target Sequences: NM_005138 NP_005129.2 O43819

Publications (1)

1
Increased mTOR activity and metabolic efficiency in mouse and human cells containing the African-centric tumor-predisposing p53 variant Pro47Ser. Keerthana Gnanapradeepan, Julia I-Ju Leu, Subhasree Basu, Thibaut Barnoud, Madeline Good, Joyce V Lee, William J Quinn, Che-Pei Kung, Rexford Ahima, Joseph A Baur, Kathryn E Wellen, Qin Liu, Zachary T Schug, Donna L George, Maureen E Murphy. eLife. 2020 November;9: [Full Text Article] [PubMed:33170774] [PMC:PMC7661039] Related Antibodies: LS-C349015.

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Proteins (10)
Over-Expression Lysate (4)
Recombinant (6)
SCO2 (10)
No (10)
GST (1)
GST, N-terminus (1)
His (1)
His, N-Terminal (1)
His-SUMO (1)
His-T7 (1)
Myc-DDK (Flag) (4)
Human (8)
293T Cells (2)
E. coli (4)
HEK 293 Cells (2)
Wheat Germ Extract (2)
Purified (2)
SCO2 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
SCO2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
30.3 kDa
20 µg/$150
SCO2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
29.81 kDa
20 µg/$150
SCO2 Protein
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E. coli
His-SUMO
41.1 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
SCO2 Protein - 12.5% SDS-PAGE of human SCO2 stained with Coomassie Blue
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Wheat Germ Extract
GST
56.2 kDa
10 µg/$479; 25 µg/$670
SCO2 Protein - Recombinant  SCO Cytochrome Oxidase Deficient Homolog 2 By SDS-PAGE
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E. coli
His-T7
28.8 kDa
10 µg/$280; 50 µg/$437; 100 µg/$700; 200 µg/$872; 1 mg/$1,978; 500 µg/$1,519; 5 mg/$3,053; 2 mg/$2,164
SCO2 Protein
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E. coli
His, N-Terminal
25.1 kDa
50 µg/$419
SCO2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
30.3 kDa
100 µg/$494
SCO2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
29.81 kDa
100 µg/$494
SCO2 Protein
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E. coli
His
50 µg/$411; 250 µg/$985; 10 µg/$276
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).