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SCN9A / Nav1.7
sodium channel, voltage-gated, type IX, alpha subunit
Scn9a encodes the alpha subunit of the type IX voltage-gated sodium channel. These channels, composed of one alpha and one or two beta subunits, mediate changes in cell permeability to sodium ions that are essential for the generation of action potentials. The alpha subunit alone can generate a functional channel in vitro >, but it's kinetic properties are modulated by beta subunits. The type IX channel is tetrodotoxin sensitive and is believed to function in hyperexcitability induced pain. At least two mRNA variants have been reported. Scn9a protein has been observed to accumulate abnormally in human neuromas.
| Gene Name: | sodium channel, voltage-gated, type IX, alpha subunit |
| Family/Subfamily: | Ion Channel , Sodium channel - voltage-gated |
| Synonyms: | SCN9A, ETHA, GEFSP7, Nav1.7, HNE-Na, Peripheral sodium channel 1, PN1, SFNP, Sodium channel 25, Neuroendocrine sodium channel, FEB3B, NE-NA, NENA |
| Target Sequences: | NM_002977 NP_002968.1 Q15858 |
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