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SCN7A
sodium channel, voltage-gated, type VII, alpha subunit
SCN7A is one of the many voltage-gated sodium channel proteins. For proper functioning of neurons and muscles during action potentials, voltage-gated sodium channels direct sodium ion diffusion for membrane depolarization. This sodium channel protein has some atypical characteristics; the similarity between the human and mouse proteins is lower compared to other orthologous sodium channel pairs. Also, the S4 segments, which sense voltage changes, have fewer positive charged residues that in other sodium channels; domain 4 has fewer arginine and lysine residues compared to other sodium channel proteins. Several alternatively spliced transcript variants exist, but the full-length natures of all of them remain unknown.
| Gene Name: | sodium channel, voltage-gated, type VII, alpha subunit |
| Family/Subfamily: | Ion Channel , Sodium channel - voltage-gated |
| Synonyms: | SCN7A, NAG, Nav2.1, SCN6A, Nav2.3, Nav2.2 |
| Target Sequences: | NM_002976 NP_002967.2 Q01118 |
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