SCN3A / Nav1.3

sodium channel, voltage-gated, type III, alpha subunit

Scn3a encodes the alpha subunit of the type III voltage-gated sodium channel. These channels, composed of one alpha and one or two beta subunits, mediate changes in cell permeability to sodium ions that are essential for the generation of action potentials. The alpha subunit alone has been shown to generate a functional channel in vitro, but it's kinetic properties are modulated by beta subunits. The type III channel has been shown to be tetrodotoxin sensitive and fast inactivated. At least two mRNA splice variants of Scn3a have been reported. These variants result from mutually exclusive alternative RNA splicing of two exons and code for two different protein isoforms, one that predominates in neonatal brain (IIIN) and another (IIIA) that predominates in the adult. Scn3a has been observed to be upregulated in epileptic CA4 pyramidal cells, cortex neurons in response to 5-day hypoxia and in dorsal root ganglion neurons in response to peripheral nerve damage.

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Products

Antibodies (9)

Type

Primary (9)

Target

SCN3A / Nav1.3 (9)

Reactivity

Human (9)

Application

IHC (6)

IHC-Fr (1)

IHC-P (3)

WB (6)

ELISA (4)

Peptide-ELISA (1)

Host

rabbit (8)

mouse (1)

Product Group

IHCPlus (2)

Isotype

IgG (3)

IgG2b,k (1)

Clonality

monoclonal mc (1)

polyclonal pc (8)

Clone

3F3 (1)

Format

Unconjugated (9)

Epitope

C-Terminus (1)

Internal (1)

Publications

No (9)

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IHC-plus™ SCN3A / Nav1.3 Antibody (Internal) LS-A8070

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(4.0) Rating

Antibody:

SCN3A / Nav1.3 Rabbit anti-Human Polyclonal (Internal) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P

Format:

Unconjugated

Price:

50 µg/$460

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SCN3A / Nav1.3 Antibody LS-C154759

Antibody:

SCN3A / Nav1.3 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-Fr, WB

Format:

Unconjugated

Price:

50 µg/$440; 100 µg/$480

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SCN3A / Nav1.3 Antibody (clone 3F3) LS-C198152

Antibody:

SCN3A / Nav1.3 Mouse anti-Human Monoclonal (3F3) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$423

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IHC-plus™ SCN3A / Nav1.3 Antibody (C-Terminus) LS-A8068

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(4.0) Rating

Antibody:

SCN3A / Nav1.3 Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P

Format:

Unconjugated

Price:

50 µg/$460

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SCN3A / Nav1.3 Antibody LS-C676460

Antibody:

SCN3A / Nav1.3 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P

Format:

Unconjugated

Price:

50 µl/$294; 100 µl/$360

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SCN3A / Nav1.3 Antibody LS-C809125

Antibody:

SCN3A / Nav1.3 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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SCN3A / Nav1.3 Antibody LS-C144741

Antibody:

SCN3A / Nav1.3 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

100 µl/$440; 200 µl/$468

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SCN3A / Nav1.3 Antibody LS-C779388

Antibody:

SCN3A / Nav1.3 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$357

Select

SCN3A / Nav1.3 Antibody LS-C496785

Antibody:

SCN3A / Nav1.3 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

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