SCN2B

sodium channel, voltage-gated, type II, beta subunit

Scn2b encodes one type of beta subunit found in voltage-gated sodium channels. These channels, composed of one alpha and one or two different beta subunits, mediate changes in cell permeability to sodium ions that are essential for the generation of action potentials. Scn2b protein, comprised of an extracellular N-terminus with an immunoglobulin-like fold and a single transmembrane domain, has been shown in brain tissues to be covalently linked through disulfide bonds to the alpha subunit. Scn2b is considered an auxiliary subunit that modulates cell-surface expression and gating, though its function in heart myocytes may be limited to cell adhesion. Scnb2 null mice display increased susceptibility to seizures. Expression of Scn2b has been shown to be suppressed with exposure to pneumococcal acute otitis media.

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Proteins (4)

Type

Over-Expression Lysate (2)

Recombinant (2)

Target

SCN2B (4)

Publications

No (4)

Tag

GST (1)

His, N-Terminal (1)

Myc-DDK (Flag) (2)

Species

Human (3)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (1)

Wheat Germ Extract (1)

Purification

Purified (1)

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Human SCN2B Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G80647

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

24.1 kDa

Price:

20 µg/$150

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Human SCN2B Protein (Recombinant GST) (Full Length) - LS-G30328

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

49.39 kDa

Price:

10 µg/$479; 25 µg/$670

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SCN2B Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G100339

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

24.1 kDa

Price:

100 µg/$494

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Human SCN2B Protein (Recombinant His, N-Terminal) - LS-G144075

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

24.1 kDa

Price:

50 µg/$419

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