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SCN11A / Nav1.9
sodium channel, voltage-gated, type XI, alpha subunit
Scn12a encodes the alpha subunit of the type XII voltage-gated sodium channel. These channels, composed of one alpha and one or two beta subunits, mediate changes in cell permeability to sodium ions that are essential for the generation of action potentials. The alpha subunit alone has been shown to generate a functional channel in vitro, but it's kinetic properties are modulated by beta subunits. Scn12a, which produces produces a persistent, tetrodotoxin-resistant current with wide overlap between activation and steady-state inactivation, has been implicated in nociceptive transmission. At least two alternative splicing variants have been reported. Scn12a is considered an attractive target for pain treatment.
| Gene Name: | sodium channel, voltage-gated, type XI, alpha subunit |
| Family/Subfamily: | Ion Channel , Sodium channel - voltage-gated |
| Synonyms: | SCN11A, HNaN, NaT, NAV1.9, PN5, SNS-2, SNS2, NaN, SCN12A |
| Target Sequences: | NM_014139 NP_054858.2 Q9UI33 |
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