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SCG5 / 7B2

secretogranin V (7B2 protein)

Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro.

Gene Name: secretogranin V (7B2 protein)
Synonyms: SCG5, 7B2, Neuroendocrine protein 7B2, p7B2, Secretogranin V (7B2 protein), Secretogranin-5, SGNE1, SgV, Secretogranin V, Pituitary polypeptide
Target Sequences: NM_003020 NP_003011.1 P05408

☰ Filters
Products
Proteins (11)
Over-Expression Lysate (4)
Recombinant (7)
SCG5 / 7B2 (11)
No (11)
GST (1)
GST, N-terminus (1)
His (2)
His-T7 (1)
Myc-DDK (Flag) (6)
Human (9)
293T Cells (2)
E. coli (3)
HEK 293 Cells (4)
Wheat Germ Extract (2)
Purified (2)
Low endotoxin level (1)
SCG5 / 7B2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
23.5 kDa
20 µg/$150
SCG5 / 7B2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
23.5 kDa
100 µg/$494
SCG5 / 7B2 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
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HEK 293 Cells
Myc-DDK (Flag)
23.7 kDa
100 µg/$494
SCG5 / 7B2 Protein - 12.5% SDS-PAGE of human SCG5 stained with Coomassie Blue
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Wheat Germ Extract
GST
50.1 kDa
2 µg/$439
SCG5 / 7B2 Protein - Recombinant  Secretogranin V By SDS-PAGE
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E. coli
His-T7
24.6 kDa
10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060
SCG5 / 7B2 Protein - Purified recombinant protein SCG5 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
23.5 kDa
20 µg/$1,107
SCG5 / 7B2 Protein - Purified recombinant protein SCG5 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
23.5 kDa
20 µg/$1,107
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293T Cells
Myc-DDK (Flag)
23.7 kDa
20 µg/$150
SCG5 / 7B2 Protein
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E. coli
His
50 µg/$361; 250 µg/$739; 10 µg/$261
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E. coli
101 AA
His
Less than 0.1 EU/µg protein (determined by LAL method).
11.22 kDa
10 mg/$4,268; 5 mg/$3,201; 1 mg/$1,868; 0.5 mg/$1,475; 200 µg/$1,103; 100 µg/$756; 50 µg/$531
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).