Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro.
|Gene Name:||secretogranin V (7B2 protein)|
|Synonyms:||SCG5, 7B2, Neuroendocrine protein 7B2, p7B2, Secretogranin V (7B2 protein), Secretogranin-5, SGNE1, SgV, Secretogranin V, Pituitary polypeptide|
|Target Sequences:||NM_003020 NP_003011.1 P05408|
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