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SCG10 / STMN2

stathmin-like 2

SCG10 / STMN2 is a member of the stathmin family of phosphoproteins. Stathmin proteins function in microtubule dynamics and signal transduction. The encoded protein plays a regulatory role in neuronal growth and is also thought to be involved in osteogenesis. Reductions in the expression of this gene have been associated with Down's syndrome and Alzheimer's disease. Alternatively spliced transcript variants have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome 6.

Gene Name: stathmin-like 2
Synonyms: STMN2, SCGN10, SCG10, Stathmin-like 2, Protein SCG10, Stathmin-2
Target Sequences: NM_007029 NP_008960.2 Q93045

Publications (2)

1
Dual leucine zipper kinase is required for retrograde injury signaling and axonal regeneration. Shin JE, Cho Y, Beirowski B, Milbrandt J, Cavalli V, DiAntonio A. Neuron. 2012 74:1015-22. [PubMed:22726832] [PMC:PMC3383631]
2
Toll-Like Receptor 9-Mediated Neuronal Innate Immune Reaction Is Associated with Initiating a Pro-Regenerative State in Neurons of the Dorsal Root Ganglia Non-Associated with Sciatic Nerve Lesion. Petr Dubový, Ivana Hradilová-Svíženská, Václav Brázda, Marek Joukal. International journal of molecular sciences. 2021 July;22:7446. [Full Text Article] [PubMed:34299065] [PMC:PMC8304752] Related Antibodies: LS-C143454.

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).