SCAP

SREBF chaperone

Escort protein required for cholesterol as well as lipid homeostasis. Regulates export of the SCAP/SREBF complex from the ER upon low cholesterol. Formation of a ternary complex with INSIG at high sterol concentrations leads to masking of an ER-export signal in SCAP and retention of the complex in the ER. Low sterol concentrations trigger release of INSIG, a conformational change in the SSC domain of SCAP, unmasking of the ER export signal, recruitment into COPII-coated vesicles, transport to the Golgi complex, proteolytic cleavage of SREBF in the Golgi, release of the transcription factor fragment of SREBF from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway.

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Products

Antibodies (12)

Type

Primary (12)

Target

SCAP (12)

Reactivity

Human (12)

Mouse (4)

Rat (3)

Application

IHC (2)

IHC-P (1)

WB (12)

Flo (1)

ELISA (8)

IF (3)

IP (1)

Peptide-ELISA (1)

Host

rabbit (11)

mouse (1)

Product Group

IHCPlus (1)

Isotype

IgG (9)

IgG1,k (1)

Clonality

monoclonal mc (1)

polyclonal pc (11)

Clone

1992C245.37.16 (1)

Format

APC Conjugated (1)

Azide-free (1)

Biotin Conjugated (1)

FITC Conjugated (1)

HRP Conjugated (1)

PE Conjugated (1)

Unconjugated (7)

Epitope

aa604-632 (7)

N-Terminus (1)

aa450-500 (1)

Publications

No (12)

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IHC-plus™ SCAP Antibody (aa604-632) LS-B9086

(4.0) Rating

Antibody:

SCAP Rabbit anti-Human Polyclonal (aa604-632) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

Flo, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

200 µl/$460

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SCAP Antibody (N-Terminus, clone 1992C245.37.16) LS-C757700

Antibody:

SCAP Mouse anti-Human Monoclonal (N-Terminus) (1992C245.37.16) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

200 µl/$393

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SCAP Antibody LS-C109427

Antibody:

SCAP Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$450

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SCAP Antibody (aa604-632) LS-C328601

Antibody:

SCAP Rabbit anti-Human Polyclonal (aa604-632) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

200 µl/$734

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SCAP Antibody (aa604-632, Biotin) LS-C282499

Antibody:

SCAP Rabbit anti-Human Polyclonal (aa604-632) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

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SCAP Antibody (aa604-632, FITC) LS-C282500

Antibody:

SCAP Rabbit anti-Human Polyclonal (aa604-632) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

FITC Conjugated

Price:

200 µl/$952

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SCAP Antibody (aa604-632, PE) LS-C282502

Antibody:

SCAP Rabbit anti-Human Polyclonal (aa604-632) (PE) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

PE Conjugated

Price:

200 µl/$952

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SCAP Antibody (aa604-632, Azide-free, HRP) LS-C282501

Antibody:

SCAP Rabbit anti-Human Polyclonal (aa604-632) (Azide-free) (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

Select

SCAP Antibody (aa604-632, APC) LS-C282498

Antibody:

SCAP Rabbit anti-Human Polyclonal (aa604-632) (APC) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

APC Conjugated

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• PE
• HRP, Azide-free
• APC

• Unconjugated
• Biotin
• FITC
• More...
  • PE
  • HRP, Azide-free
  • APC

Select

SCAP Antibody (aa450-500) LS-C290222

Antibody:

SCAP Rabbit anti-Human Polyclonal (aa450-500) Antibody

Reactivity:

Human

Applications:

IP, WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$514

Select

SCAP Antibody LS-C753111

Antibody:

SCAP Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

100 µg/$341

Select

SCAP Antibody LS-C803915

Antibody:

SCAP Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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