order histories, retained contact details for faster checkout, review submissions, and special promotions.
Forgot password?
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Locations
Orders Processing,
Shipping & Receiving,
Warehouse
2 Shaker Rd Suites
B001/B101
Shirley, MA 01464
Production Lab
Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036
Telephone Numbers
Tel: +1 (206) 374-1102
Fax: +1 (206) 577-4565
Contact Us
Additional Contact Details
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Forgot password?
order histories, retained contact details for faster checkout, review submissions, and special promotions.
SBF1 / MTMR5
SET binding factor 1
Myotubularin-related protein 5 (MTMR5), a myotubularin-related phosphatase, has been shown to be similar to dual-specificity phosphatases of the myotubularin group; however MTMR5 also has been shown to lack several crucial residues in the catalytic pocket which render it catalytically inactive as a phosphatase. The pocket has been shown to bind phosphorylated synthetic substrates which suggests that it may be a protective factor that competes with functional phosphatases for substrate interaction. MTMR5 also has been shown to bind the phosphoinositides PtdIns(3,4)P2 and PtdIns(3,4,5)P3 in a PH (pleckstrin homology) domain. Also known as SET-binding factor 1 (SBF1), this protein has been shown to interact in vitro with SET (Suvar3-9, Enhancer of zeste, trithorax) domains of nuclear proteins. Mutated forms of SBF1 have been shown to be highly oncogenic, and a conserved motif in SBF1 that mediates interactions with SET domains in vitro has been demonstrated to be necessary and sufficient for oncogenic activity. Further, recent studies have demonstrated a role for MTMR5 in spermatogenesis and germ cell differentiation.
| Gene Name: | SET binding factor 1 |
| Family/Subfamily: | Protein Phosphatase Regulatory Subunit , Myotubularin-Related |
| Synonyms: | SBF1, DENND7A, MTMR 5, Myotubularin-related protein 5, SET binding factor 1, SET-binding factor 1, Myotubularin related 5, MTMR5 |
| Target Sequences: | U93181 AAC39675.1 O95248 |
If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.
