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Negative regulator of store-operated Ca2+ entry (SOCE) involved in protecting cells from Ca2+ overfilling. In response to cytosolic Ca2+ elevation after endoplasmic reticulum Ca2+ refilling, promotes a slow inactivation of STIM (STIM1 or STIM2)-dependent SOCE activity: possibly act by facilitating the deoligomerization of STIM to efficiently turn off ORAI when the endoplasmic reticulum lumen is filled with the appropriate Ca2+ levels, and thus preventing the overload of the cell with excessive Ca2+ ions.
Gene Name: | transmembrane protein 66 |
Synonyms: | SARAF, FOAP-7, HSPC035, Protein FOAP-7, SARAF short isoform, SARAF long isoform, Transmembrane protein 66, Npd003, TMEM66, XTP3 |
Target Sequences: | NM_016127 NP_057211.4 Q96BY9 |
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