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SARA2 / SAR1B

SAR1 homolog B (S. cerevisiae)

SARA2 / SAR1B is a small GTPase that acts as a homodimer. The encoded protein is activated by the guanine nucleotide exchange factor PREB and is involved in protein transport from the endoplasmic reticulum to the Golgi. This protein is part of the COPII coat complex. Defects in this gene are a cause of chylomicron retention disease (CMRD), also known as Anderson disease (ANDD). Two transcript variants encoding the same protein have been found for this gene.

Gene Name: SAR1 homolog B (S. cerevisiae)
Family/Subfamily: Ras GTPase superfamily IPR001806 , not assigned-Ras GTPase superfamily IPR001806
Synonyms: SAR1B, ANDD, CMRD, GTP-binding protein SAR1b, GTP-binding protein Sara, SARB, SAR1a gene homolog 2, SARA2, GTBPB, GTP-binding protein B, SAR1 homolog B (S. cerevisiae)
Target Sequences: NM_016103 NP_057187.1 Q9Y6B6

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).