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SAMHD1

SAM domain and HD domain 1

Host restriction nuclease that blocks early-stage virus replication in dendritic and other myeloid cells. Likewise, suppresses LINE-1 retrotransposon activity. May function by reducing the cellular dNTP levels to levels too low for retroviral reverse transcription to occur. May play a role in mediating proinflammatory responses to TNF-alpha signaling.

Gene Name: SAM domain and HD domain 1
Synonyms: SAMHD1, AGS5, CHBL2, DCIP, HDDC1, Monocyte protein 5, MOP-5, MOP5, SBBI88, Mg11, SAM domain and HD domain 1
Target Sequences: NM_015474 NP_056289.2 Q9Y3Z3

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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).