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SALL3
spalt-like transcription factor 3
SALL3 is a sal-like C2H2-type zinc-finger protein, and belongs to a family of evolutionarily conserved genes found in species as diverse as Drosophila, C. elegans, and vertebrates. Mutations in some of these genes are associated with congenital disorders in human, suggesting their importance in embryonic development. This protein binds to DNA methyltransferase 3 alpha (DNMT3A), and reduces DNMT3A-mediated CpG island methylation. It is suggested that silencing of this gene, resulting in acceleration of DNA methylation, may have a role in oncogenesis.
| Gene Name: | spalt-like transcription factor 3 |
| Synonyms: | SALL3, C2H2 zinc finger protein SALL3, HSALL3, Sal-like 3 (Drosophila), Zinc finger protein 796, ZNF796, Sal (Drosophila)-like 3, Sal-like protein 3, Spalt-like zinc finger protein, Zinc finger protein SALL3 |
| Target Sequences: | AJ007421 CAB65124.1 Q9BXA9 |
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