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S-adenosylhomocysteine hydrolase belongs to the adenosylhomocysteinase family. It catalyzes the reversible hydrolysis of S-adenosylhomocysteine (AdoHcy) to adenosine (Ado) and L-homocysteine (Hcy). Thus, it regulates the intracellular S-adenosylhomocysteine (SAH) concentration thought to be important for transmethylation reactions. Deficiency in this protein is one of the different causes of hypermethioninemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Gene Name: | adenosylhomocysteinase |
Synonyms: | AHCY, Adenosylhomocysteinase, AdoHcyase, SAHH |
Target Sequences: | NM_000687 NP_000678.1 P23526 |
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