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S1PR1 / EDG1 / S1P1

sphingosine-1-phosphate receptor 1

G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. Signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. Plays an important role in cell migration, probably via its role in the reorganization of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. Required for normal chemotaxis toward sphingosine 1-phosphate. Required for normal embryonic heart development and normal cardiac morphogenesis. Plays an important role in the regulation of sprouting angiogenesis and vascular maturation. Inhibits sprouting angiogenesis to prevent excessive sprouting during blood vessel development. Required for normal egress of mature T-cells from the thymus into the blood stream and into peripheral lymphoid organs. Plays a role in the migration of osteoclast precursor cells, the regulation of bone mineralization and bone homeostasis (By similarity). Plays a role in responses to oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine by pulmonary endothelial cells and in the protection against ventilator-induced lung injury.

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Antibodies (58)

ELISA Kits (9)

Proteins (2)

Type

Cell-Based (1)

Competitive EIA (1)

Custom (2)

Primary (58)

Recombinant (2)

Sandwich (5)

Target

S1PR1 / EDG1 / S1P1 (69)

Reactivity

Human (60)

Mouse (43)

Rat (19)

Bovine (6)

Chimpanzee (3)

Dog (5)

Gibbon (3)

Hamster (4)

Horse (4)

Monkey (1)

Orangutan (3)

Pig (5)

Rabbit (4)

Zebrafish (1)

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Application

IHC (16)

IHC-P (11)

WB (50)

Flo (5)

ELISA (24)

ICC (1)

IF (13)

IP (2)

Peptide-ELISA (6)

Host

rabbit (52)

mouse (6)

Product Group

GPCR Database Antibodies (2)

IHCPlus (2)

PathPlus Cancer (2)

Isotype

IgG (37)

IgG1,k (1)

IgG2a (3)

IgG2b (2)

Clonality

monoclonal mc (6)

polyclonal pc (52)

Clone

1E3H5 (1)

218713 (2)

2B9 (1)

2E12 (1)

8E4H5 (1)

Format

96-Well Microplate (2)

96-Well Strip Plate (7)

APC Conjugated (3)

Azide-free (1)

Biotin Conjugated (4)

FITC Conjugated (4)

HRP Conjugated (4)

PE Conjugated (3)

Unconjugated (40)

Epitope

aa10-39 (7)

aa226-275 (4)

pThr236 (3)

180-260 aa (2)

C-Terminus (2)

20-100 aa, N-terminal (1)

Cytoplasmic Domain (1)

Internal (1)

Thr48 (1)

aa1-50 (1)

aa183-232 (1)

aa206-255 (1)

aa241-253 (1)

aa311-335 (1)

aa48-97 (1)

aa5-54 (1)

aa86-382 (1)

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Publications

No (67)

Yes (2)

Sample Type

Adherent Cell Cultures (1)

Cell Lysates (2)

Plasma (4)

Serum (4)

Tissue Homogenates (4)

Tag

GST (1)

GST, N-terminus (1)

Species

Human (2)

Source

Wheat Germ Extract (2)

Purification

Purified (1)

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IHC-plus™ S1PR1 / EDG1 / S1P1 Antibody LS-B6370

(5.0) Rating

(1) Publication(s)

Antibody:

S1PR1 / EDG1 / S1P1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$460

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PathPlus™ S1PR1 / EDG1 / S1P1 Antibody (Cytoplasmic Domain) LS-A1013

Cancer

Fast Shipping

(5.0) Rating

Antibody:

S1PR1 / EDG1 / S1P1 Rabbit anti-Human Polyclonal (Cytoplasmic Domain) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P

Format:

Unconjugated

Price:

50 µg/$440

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S1PR1 / EDG1 / S1P1 Antibody (aa241-253) LS-C11168

(4.0) Rating

(1) Publication(s)

Antibody:

S1PR1 / EDG1 / S1P1 Rabbit anti-Human Polyclonal (aa241-253) Antibody

Reactivity:

Mouse, Dog, Bovine, Rat, Hamster, Pig, Horse, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

1 Each/$431

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S1PR1 / EDG1 / S1P1 Antibody (aa10-39) LS-C100385

Antibody:

S1PR1 / EDG1 / S1P1 Rabbit anti-Human Polyclonal (aa10-39) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

400 µl/$393

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S1PR1 / EDG1 / S1P1 Antibody (clone 218713, PE) LS-C65192

Antibody:

S1PR1 / EDG1 / S1P1 Mouse anti-Human Monoclonal (PE) (218713) Antibody

Reactivity:

Human

Applications:

Flo

Format:

PE Conjugated

Price:

100 Tests/$860

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S1PR1 / EDG1 / S1P1 Antibody (clone 218713, APC) LS-C65191

Antibody:

S1PR1 / EDG1 / S1P1 Mouse anti-Human Monoclonal (APC) (218713) Antibody

Reactivity:

Human

Applications:

Flo

Format:

APC Conjugated

Price:

100 Tests/$896

• PE
• APC

• PE
• APC

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S1PR1 / EDG1 / S1P1 Antibody LS-C370277

Antibody:

S1PR1 / EDG1 / S1P1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

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S1PR1 / EDG1 / S1P1 Antibody (HRP) LS-C370275

Antibody:

S1PR1 / EDG1 / S1P1 Rabbit anti-Human Polyclonal (HRP) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

HRP Conjugated

Price:

50 µg/$294; 100 µg/$360

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S1PR1 / EDG1 / S1P1 Antibody (Biotin) LS-C370289

Antibody:

S1PR1 / EDG1 / S1P1 Rabbit anti-Human Polyclonal (Biotin) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Biotin Conjugated

Price:

50 µg/$294; 100 µg/$360

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S1PR1 / EDG1 / S1P1 Antibody (FITC) LS-C370276

Antibody:

S1PR1 / EDG1 / S1P1 Rabbit anti-Human Polyclonal (FITC) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

FITC Conjugated

Price:

50 µg/$294; 100 µg/$360

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

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S1PR1 / EDG1 / S1P1 Antibody (Internal) LS-C368514

Antibody:

S1PR1 / EDG1 / S1P1 Rabbit anti-Human Polyclonal (Internal) Antibody

Reactivity:

Mouse, Bovine, Rat, Human

Applications:

ICC, IF, WB

Format:

Unconjugated

Price:

30 µl/$255; 100 µl/$299; 200 µl/$351

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PathPlus™ S1PR1 / EDG1 / S1P1 Antibody (C-Terminus) LS-A1012

Cancer

Fast Shipping

(5.0) Rating

Antibody:

S1PR1 / EDG1 / S1P1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P

Format:

Unconjugated

Price:

50 µg/$460

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S1PR1 / EDG1 / S1P1 Antibody LS-C83928

Antibody:

S1PR1 / EDG1 / S1P1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

0.1 mg/$460

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S1PR1 / EDG1 / S1P1 Antibody (aa226-275) LS-C151690

Antibody:

S1PR1 / EDG1 / S1P1 Rabbit anti-Human Polyclonal (aa226-275) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

Select

IHC-plus™ S1PR1 / EDG1 / S1P1 Antibody LS-B9439

(4.0) Rating

Antibody:

S1PR1 / EDG1 / S1P1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P

Format:

Unconjugated

Price:

100 µg/$460

Select

S1PR1 / EDG1 / S1P1 Antibody (aa206-255) LS-C118016

Antibody:

S1PR1 / EDG1 / S1P1 Rabbit anti-Human Polyclonal (aa206-255) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

Select

S1PR1 / EDG1 / S1P1 Antibody (aa5-54) LS-C120573

Antibody:

S1PR1 / EDG1 / S1P1 Rabbit anti-Human Polyclonal (aa5-54) Antibody

Reactivity:

Human

Applications:

IF, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

Select

S1PR1 / EDG1 / S1P1 Antibody LS-C406077

Antibody:

S1PR1 / EDG1 / S1P1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450

Select

S1PR1 / EDG1 / S1P1 Antibody (clone 8E4H5) LS-C828381

Antibody:

S1PR1 / EDG1 / S1P1 Mouse anti-Human Monoclonal (8E4H5) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IHC, WB

Format:

Unconjugated

Price:

100 µg/$459

Select

S1PR1 / EDG1 / S1P1 Antibody (20-100 aa, N-terminal) LS-C383251

Antibody:

S1PR1 / EDG1 / S1P1 Rabbit anti-Human Polyclonal (20-100 aa, N-terminal) Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

Select

S1PR1 / EDG1 / S1P1 Antibody (clone 2B9) LS-C746128

Antibody:

S1PR1 / EDG1 / S1P1 Mouse anti-Human Monoclonal (2B9) Antibody

Reactivity:

Human

Applications:

Flo, IF, IP, WB

Format:

Unconjugated

Price:

0.1 mg/$505

Select

S1PR1 / EDG1 / S1P1 Antibody (clone 1E3H5) LS-C828320

Antibody:

S1PR1 / EDG1 / S1P1 Mouse anti-Human Monoclonal (1E3H5) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, WB

Format:

Unconjugated

Price:

100 µg/$459

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Human S1PR1 / EDG1 / S1P1 Protein (Recombinant GST) (Full Length) - LS-G28289

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

69.2 kDa

Price:

2 µg/$439

Select

S1PR1 / EDG1 / S1P1 Antibody (Thr48) LS-C177084

Antibody:

S1PR1 / EDG1 / S1P1 Rabbit anti-Human Polyclonal (Thr48) Antibody

Reactivity:

Human

Applications:

IF, IHC, WB

Format:

Unconjugated

Price:

50 µl/$321; 100 µl/$403

Select

S1PR1 / EDG1 / S1P1 Antibody (180-260 aa) LS-C381780

Antibody:

S1PR1 / EDG1 / S1P1 Rabbit anti-Human Polyclonal (180-260 aa) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

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