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Unfortunately, the antibody (ID:73427) is no longer available.

Below is a list of antibodies to the same protein target. You may also try your search again using the search box at the top of the page. Please contact us if you have any questions.



S100A8 / MRP8

S100 calcium binding protein A8

S100A8 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It can induce neutrophil chemotaxis and adhesion. Predominantly found as calprotectin (S100A8/A9) which has a wide plethora of intra- and extracellular functions. The intracellular functions include: facilitating leukocyte arachidonic acid trafficking and metabolism, modulation of the tubulin-dependent cytoskeleton during migration of phagocytes and activation of the neutrophilic NADPH-oxidase. Activates NADPH-oxidase by facilitating the enzyme complex assembly at the cell membrane, transferring arachidonic acid, an essential cofactor, to the enzyme complex and S100A8 contributes to the enzyme assembly by directly binding to NCF2/P67PHOX. The extracellular functions involve proinfammatory, antimicrobial, oxidant-scavenging and apoptosis-inducing activities. Its proinflammatory activity includes recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to pattern recognition receptors such as Toll-like receptor 4 (TLR4) and receptor for advanced glycation endproducts (AGER). Binding to TLR4 and AGER activates the MAP-kinase and NF-kappa-B signaling pathways resulting in the amplification of the proinflammatory cascade. Has antimicrobial activity towards bacteria and fungi and exerts its antimicrobial activity probably via chelation of Zn2+ which is essential for microbial growth. Can induce cell death via autophagy and apoptosis and this occurs through the cross-talk of mitochondria and lysosomes via reactive oxygen species (ROS) and the process involves BNIP3. Can regulate neutrophil number and apoptosis by an anti-apoptotic effect; regulates cell survival via ITGAM/ITGB and TLR4 and a signaling mechanism involving MEK-ERK. Its role as an oxidant scavenger has a protective role in preventing exaggerated tissue damage by scavenging oxidants. Can act as a potent amplifier of inflammation in autoimmunity as well as in cancer development and tumor spread.

Gene Name: S100 calcium binding protein A8
Synonyms: S100A8, 60B8AG, CFAG, CAGA, Calgranulin A, Calgranulin-A, Calprotectin L1L subunit, Cystic fibrosis antigen, CGLA, L1Ag, NIF, p8, Protein S100-A8, MRP8, Urinary stone protein band A, CP-10, MA387, MRP-8
Target Sequences: NM_002964 NP_002955.2 P05109

Filtered By: None
Target
s100a8-mrp8 (91)
Reactivity
Human (58)
Mouse (31)
Rat (20)
Bovine (4)
Cat (10)
Chimpanzee (3)
Cow (1)
Dog (10)
Guinea pig (8)
Horse (2)
Monkey (10)
Pig (13)
Rabbit (2)
Application
IHC (11)
IHC-Fr (1)
IHC-P (22)
WB (57)
Flo (8)
ELISA (23)
ICC (8)
IF (3)
Host
rabbit (45)
mouse (38)
goat (3)
rat (3)
sheep (2)
Isotype
IgG (41)
IgG,l (1)
IgG1 (10)
IgG1,k (5)
IgG2a,k (1)
IgG2b (4)
IgG2b,k (7)
IgG2b,l (1)
IgM (2)
Clonality
monoclonal mc (41)
polyclonal pc (50)
Clone
1B3 (1)
335806 (1)
48M5F4 (2)
48M7C7 (2)
48M7F9 (2)
63N13G5 (2)
7C12/4 (1)
8-5C2 (2)
ABM41E4 (1)
ABM4D13 (1)
ABM4G30 (1)
CF-145 (3)
IMG48M7C7 (1)
MAC387 (1)
S13-67 (2)
SA6279 (1)
Format
AP Conjugated (1)
APC Conjugated (1)
Azide-free (5)
Biotin Conjugated (16)
FITC Conjugated (15)
HRP Conjugated (6)
PE Conjugated (1)
Unconjugated (51)
Epitope
aa1-93 (14)
aa1-89 (13)
aa2-89 (8)
C-Terminus (4)
aa2-82 (3)
aa2-105 (2)
N-Terminus (1)
aa 1-93 (1)
aa2-101 (1)
aa2-80 (1)
aa2-93 (1)
aa2-98 (1)
aa49-62 (1)
Publications
No (91)
Showing 1-25 out of 91 results
Anti-S100A8 / MRP8 Antibody (clone CF-145) IHC-plus™ LS-B1618

Mouse Monoclonal [clone CF-145] (IgG2b) to Human S100A8 / MRP8
Human
Flo IF IHC-P WB
Unconjugated
Anti-S100A8 / MRP8 Antibody (clone CF-145, FITC) IHC-plus™ LS-B2836

Mouse Monoclonal [clone CF-145] (IgG2b) to Human S100A8 / MRP8
Human
Flo IF IHC-P WB
FITC Conjugated
Anti-S100A8 / MRP8 Antibody (FITC) IHC-plus™ LS-B2247

Mouse Monoclonal (IgG1) to Human S100A8 / MRP8
Rabbit, Dog, Bovine, Rat, Pig, Cat, Horse, Human, Monkey
Flo IHC-P
FITC Conjugated
Anti-S100A8 / MRP8 Antibody (Azide-free) IHC-plus™ LS-B2256

Mouse Monoclonal (IgG1) to Human S100A8 / MRP8
Mouse, Dog, Guinea pig, Rat, Pig, Cat, Human, Monkey
IHC-P
Unconjugated, Azide-free
Anti-S100A8 / MRP8 Antibody (aa1-89, clone 335806) LS-C150242

Rat Monoclonal [clone 335806] (IgG2b) to Mouse S100A8 / MRP8
Mouse
ICC WB
Unconjugated
Anti-S100A8 / MRP8 Antibody (clone CF-145, Biotin) LS-C62797

Mouse Monoclonal [clone CF-145] (IgG2b) to Human S100A8 / MRP8
Human
Flo WB
Biotin Conjugated
Anti-S100A8 / MRP8 Antibody (clone MAC387) LS-C89474

Mouse Monoclonal [clone MAC387] (IgG1) to Human S100A8 / MRP8
Rabbit, Dog, Bovine, Rat, Pig, Cat, Horse, Human, Monkey
Flo IHC-Fr IHC-P
Unconjugated
Anti-S100A8 / MRP8 Antibody (clone 1B3) LS-C139278

Mouse Monoclonal [clone 1B3] (IgG2a,k) to Human S100A8 / MRP8
Human
ELISA WB
Unconjugated
Anti-S100A8 / MRP8 Antibody LS-C35249

Goat Polyclonal (IgG) to Mouse S100A8 / MRP8
Mouse
ELISA ICC WB
Unconjugated
Anti-S100A8 / MRP8 Antibody LS-C150244

Goat Polyclonal (IgG) to Mouse S100A8 / MRP8
Mouse
ELISA ICC WB
Unconjugated
Anti-S100A8 / MRP8 Antibody (clone 8-5C2) LS-C96230

Mouse Monoclonal [clone 8-5C2]
Human
ELISA IHC-P
Unconjugated
Anti-S100A8 / MRP8 Antibody (aa1-89) LS-C296322

Rabbit Polyclonal (IgG) to Cow S100A8 / MRP8
Cow
WB
Unconjugated
Anti-S100A8 / MRP8 Antibody LS-C331639

Rabbit Polyclonal (IgG) to Human S100A8 / MRP8
Human
IF IHC WB
Unconjugated
Anti-S100A8 / MRP8 Antibody (aa1-93) LS-C150054

Sheep Polyclonal (IgG) to Human S100A8 / MRP8
Human
Flo ICC WB
Unconjugated
Anti-S100A8 / MRP8 Antibody (aa 1-93) IHC-plus™ LS-B14934

Rabbit Polyclonal (IgG) to Human S100A8 / MRP8
Human
ELISA IHC-P
Unconjugated
Anti-S100A8 / MRP8 Antibody LS-C10050

Mouse Monoclonal (IgM) to Human S100A8 / MRP8
Human
Flo WB
Unconjugated
Anti-S100A8 / MRP8 Antibody (clone 7C12/4) LS-C140097

Mouse Monoclonal [clone 7C12/4] (IgM) to Human S100A8 / MRP8
Human
Flo WB
Unconjugated
Anti-S100A8 / MRP8 Antibody (aa2-89) LS-C407954

Rabbit Polyclonal to Mouse S100A8 / MRP8
Mouse, Rat
IHC-P WB
Unconjugated
Anti-S100A8 / MRP8 Antibody LS-C490416

Rabbit Polyclonal (IgG) to Mouse S100A8 / MRP8
Mouse, Rat
IHC-P WB
Unconjugated
Anti-S100A8 / MRP8 Antibody (aa1-93) LS-C370278

Rabbit Polyclonal (IgG) to Mouse S100A8 / MRP8
Mouse
ELISA IHC-P
Unconjugated
Anti-S100A8 / MRP8 Antibody (aa1-93, HRP) LS-C370282

Rabbit Polyclonal (IgG) to Mouse S100A8 / MRP8
Mouse
ELISA IHC
HRP Conjugated
Anti-S100A8 / MRP8 Antibody (aa1-93, Biotin) LS-C370285

Rabbit Polyclonal (IgG) to Mouse S100A8 / MRP8
Mouse
ELISA IHC
Biotin Conjugated
Anti-S100A8 / MRP8 Antibody (aa1-93, FITC) LS-C370283

Rabbit Polyclonal (IgG) to Mouse S100A8 / MRP8
Mouse
ELISA IHC
FITC Conjugated
Anti-S100A8 / MRP8 Antibody LS-C192895

Rabbit Polyclonal to Human S100A8 / MRP8
Mouse, Rat, Human
IHC WB
Unconjugated
Anti-S100A8 / MRP8 Antibody (aa1-93, Biotin) LS-C418005

Mouse Monoclonal (IgG) to Human S100A8 / MRP8
Human
ICC WB
Biotin Conjugated

Selected:

If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).


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