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Unfortunately, the antibody (ID:155997) is no longer available.

Below is a list of antibodies to the same protein target. You may also try your search again using the search box at the top of the page. Please contact us if you have any questions.



S100A8 / MRP8

S100 calcium binding protein A8

S100A8 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It can induce neutrophil chemotaxis and adhesion. Predominantly found as calprotectin (S100A8/A9) which has a wide plethora of intra- and extracellular functions. The intracellular functions include: facilitating leukocyte arachidonic acid trafficking and metabolism, modulation of the tubulin-dependent cytoskeleton during migration of phagocytes and activation of the neutrophilic NADPH-oxidase. Activates NADPH-oxidase by facilitating the enzyme complex assembly at the cell membrane, transferring arachidonic acid, an essential cofactor, to the enzyme complex and S100A8 contributes to the enzyme assembly by directly binding to NCF2/P67PHOX. The extracellular functions involve proinfammatory, antimicrobial, oxidant-scavenging and apoptosis-inducing activities. Its proinflammatory activity includes recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to pattern recognition receptors such as Toll-like receptor 4 (TLR4) and receptor for advanced glycation endproducts (AGER). Binding to TLR4 and AGER activates the MAP-kinase and NF-kappa-B signaling pathways resulting in the amplification of the proinflammatory cascade. Has antimicrobial activity towards bacteria and fungi and exerts its antimicrobial activity probably via chelation of Zn2+ which is essential for microbial growth. Can induce cell death via autophagy and apoptosis and this occurs through the cross-talk of mitochondria and lysosomes via reactive oxygen species (ROS) and the process involves BNIP3. Can regulate neutrophil number and apoptosis by an anti-apoptotic effect; regulates cell survival via ITGAM/ITGB and TLR4 and a signaling mechanism involving MEK-ERK. Its role as an oxidant scavenger has a protective role in preventing exaggerated tissue damage by scavenging oxidants. Can act as a potent amplifier of inflammation in autoimmunity as well as in cancer development and tumor spread.

Gene Name: S100 calcium binding protein A8
Synonyms: S100A8, 60B8AG, CFAG, CAGA, Calgranulin A, Calgranulin-A, Calprotectin L1L subunit, Cystic fibrosis antigen, CGLA, L1Ag, NIF, p8, Protein S100-A8, MRP8, Urinary stone protein band A, CP-10, MA387, MRP-8
Target Sequences: NM_002964 NP_002955.2 P05109

Publications (1)

1
NFATc1 supports imiquimod-induced skin inflammation by suppressing IL-10 synthesis in B cells. Alrefai H, Muhammad K, Rudolf R, Pham DA, Klein-Hessling S, Patra AK, Avots A, Bukur V, Sahin U, Tenzer S, Goebeler M, Kerstan A, Serfling E. Nature communications. 2016 7:11724. (WB; Human) [Full Text Article] [PubMed:27222343] [PMC:PMC4894959]

Filtered By: None
Target
s100a8-mrp8 (135)
Reactivity
Human (90)
Mouse (42)
Rat (25)
Bovine (10)
Cat (10)
Chimpanzee (3)
Cow (8)
Dog (10)
Guinea pig (8)
Horse (2)
Monkey (10)
Pig (20)
Rabbit (2)
Application
IHC (77)
IHC-Fr (1)
IHC-P (25)
WB (101)
Flo (7)
ELISA (27)
ICC (11)
IF (3)
IP (8)
Peptide-ELISA (1)
Host
rabbit (72)
mouse (58)
goat (2)
rat (2)
sheep (1)
Isotype
IgG (78)
IgG,l (1)
IgG1 (11)
IgG1,k (12)
IgG2a,k (1)
IgG2b (3)
IgG2b,k (7)
IgG2b,l (1)
IgM (2)
Clonality
monoclonal mc (60)
polyclonal pc (75)
Clone
1A1C1 (1)
1B3 (1)
48M5F4 (2)
48M7C7 (2)
48M7F9 (2)
63N13G5 (2)
7C12/4 (1)
8-5C2 (2)
ABM41E4 (1)
ABM4D13 (1)
ABM4G30 (1)
CF-145 (3)
IMG48M7C7 (1)
MAC 387 (1)
MAC387 (1)
S13-67 (2)
SA6279 (1)
Format
AP Conjugated (1)
APC (8)
APC Conjugated (9)
Azide-free (5)
Biotin Conjugated (19)
Cy3 Conjugated (8)
Cy7 Conjugated (8)
FITC Conjugated (18)
HRP Conjugated (14)
PE Conjugated (9)
Unconjugated (49)
Epitope
aa1-89 (34)
aa1-93 (30)
aa2-89 (8)
C-Terminus (4)
aa2-82 (3)
aa2-105 (2)
N-Terminus (1)
aa 1-93 (1)
aa2-101 (1)
aa2-80 (1)
aa2-93 (1)
aa2-98 (1)
aa49-62 (1)
Publications
No (135)
Showing 1-25 out of 135 results
Anti-S100A8 / MRP8 Antibody (clone CF-145) IHC-plus™ LS-B1618
Anti-S100A8 antibody IHC of human spleen, neutrophils. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B1618 concentration 5 ug/ml.

Mouse Monoclonal [clone CF-145] (IgG2b) to Human S100A8 / MRP8
Human
Flo IF IHC IHC-P WB
Unconjugated
Anti-S100A8 / MRP8 Antibody (clone CF-145, FITC) IHC-plus™ LS-B2836
Anti-S100A8 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2836 dilution 1:50. This image was taken for the unconjugated form of this product. Other forms have not been tested.

Mouse Monoclonal [clone CF-145] (IgG2b) to Human S100A8 / MRP8
Human
Flo IF IHC IHC-P WB
FITC Conjugated
Anti-S100A8 / MRP8 Antibody (FITC) IHC-plus™ LS-B2247
Anti-S100A8 antibody IHC of human spleen, granulocytes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2247 dilution 1:50. This image was taken for the unconjugated form of this product. Other forms have not been tested.

Mouse Monoclonal (IgG1) to Human S100A8 / MRP8
Rabbit, Dog, Bovine, Rat, Pig, Cat, Horse, Human, Monkey
Flo IHC IHC-P
FITC Conjugated
Anti-S100A8 / MRP8 Antibody (clone MAC 387, Azide-free) IHC-plus™ LS-B2256
Anti-S100A8 antibody IHC of human liver, hepatocytes and macrophages. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2256 concentration 5 ug/ml. This image was taken for the unmodified form of this product. Other forms have not been tested.

Mouse Monoclonal [clone MAC 387] (IgG1) to Human S100A8 / MRP8
Mouse, Dog, Guinea pig, Rat, Pig, Cat, Human, Monkey
IHC IHC-P
Unconjugated, Azide-free
Anti-S100A8 / MRP8 Antibody (clone CF-145, Biotin) LS-C62797

Mouse Monoclonal [clone CF-145] (IgG2b) to Human S100A8 / MRP8
Human
Flo WB
Biotin Conjugated
Anti-S100A8 / MRP8 Antibody (clone MAC387) LS-C89474

Mouse Monoclonal [clone MAC387] (IgG1) to Human S100A8 / MRP8
Rabbit, Dog, Bovine, Rat, Pig, Cat, Horse, Human, Monkey
Flo IHC IHC-Fr IHC-P
Unconjugated
Anti-S100A8 / MRP8 Antibody (clone 1B3) LS-C139278
Detection limit for recombinant GST tagged S100A8 is approximately 0.3 ng/ml as a capture antibody.

Mouse Monoclonal [clone 1B3] (IgG2a,k) to Human S100A8 / MRP8
Human
ELISA WB
Unconjugated
Anti-S100A8 / MRP8 Antibody LS-C35249

Goat Polyclonal (IgG) to Mouse S100A8 / MRP8
Mouse
ELISA ICC WB
Unconjugated
Anti-S100A8 / MRP8 Antibody (clone 8-5C2) LS-C96230
IHC of S100A8 antibody LS-C96230. Formalin-fixed, paraffin-embedded human spleen.
IHC of S100A8 antibody LS-C96230. Formalin-fixed, paraffin-embedded human tonsil.

Mouse Monoclonal [clone 8-5C2]
Human
ELISA IHC IHC-P
Unconjugated
Anti-S100A8 / MRP8 Antibody (aa1-89) LS-C296322
Western blot of recombinant S100A8 / MRP8.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

Rabbit Polyclonal (IgG) to Cow S100A8 / MRP8
Bovine, Cow
WB
Unconjugated
Anti-S100A8 / MRP8 Antibody (aa1-93) LS-C292506

Mouse Monoclonal (IgG) to Human S100A8 / MRP8
Human
ICC IHC IP WB
Unconjugated
Anti-S100A8 / MRP8 Antibody LS-C331639
Immunohistochemistry of paraffin-embedded human esophageal cancer tissue.
Immunohistochemistry of paraffin-embedded human esophageal cancer tissue.

Rabbit Polyclonal (IgG) to Human S100A8 / MRP8
Human
IF IHC WB
Unconjugated
Anti-S100A8 / MRP8 Antibody (aa1-93, FITC) LS-C692993

Mouse Monoclonal (IgG) to Human S100A8 / MRP8
Human
ICC IHC IP WB
FITC Conjugated
Anti-S100A8 / MRP8 Antibody (aa1-93, Cy3) LS-C701325

Mouse Monoclonal (IgG) to Human S100A8 / MRP8
Human
ICC IHC IP WB
Cy3 Conjugated
Anti-S100A8 / MRP8 Antibody (aa1-93, HRP) LS-C710350

Mouse Monoclonal (IgG) to Human S100A8 / MRP8
Human
ICC IHC IP WB
HRP Conjugated
Anti-S100A8 / MRP8 Antibody (aa1-93, APC, Cy7) LS-C733399

Mouse Monoclonal (IgG) to Human S100A8 / MRP8
Human
ICC IHC IP WB
APC, Cy7 Conjugated
Anti-S100A8 / MRP8 Antibody (aa1-93, APC) LS-C739999

Mouse Monoclonal (IgG) to Human S100A8 / MRP8
Human
ICC IHC IP WB
APC Conjugated
Anti-S100A8 / MRP8 Antibody (aa1-93, Biotin) LS-C686343

Mouse Monoclonal (IgG) to Human S100A8 / MRP8
Human
ICC IHC IP WB
Biotin Conjugated
Anti-S100A8 / MRP8 Antibody (aa1-93, PE) LS-C724411

Mouse Monoclonal (IgG) to Human S100A8 / MRP8
Human
ICC IHC IP WB
PE Conjugated
Anti-S100A8 / MRP8 Antibody (aa2-89) LS-C407954
MRP8 antibody IHC-paraffin. IHC(P): Mouse Spleen Tissue.
MRP8 antibody IHC-paraffin. IHC(P): Rat Spleen Tissue.

Rabbit Polyclonal to Mouse S100A8 / MRP8
Mouse, Rat
IHC IHC-P WB
Unconjugated
Anti-S100A8 / MRP8 Antibody LS-C490416
Immunohistochemistry - Paraffin Image
Immunohistochemistry - Paraffin Image

Rabbit Polyclonal (IgG) to Mouse S100A8 / MRP8
Mouse, Rat
IHC IHC-P WB
Unconjugated
Anti-S100A8 / MRP8 Antibody (aa 1-93) IHC-plus™ LS-B14934
Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)

Rabbit Polyclonal (IgG) to Human S100A8 / MRP8
Human
ELISA IHC IHC-P
Unconjugated
Anti-S100A8 / MRP8 Antibody LS-C489077

Rabbit Polyclonal to Mouse S100A8 / MRP8
Mouse
ELISA IHC IHC-P
Unconjugated
Anti-S100A8 / MRP8 Antibody (aa1-93) LS-C370278
Immunohistochemistry of paraffin-embedded human tonsil tissue using antibody at 1:100 dilution..

Rabbit Polyclonal (IgG) to Mouse S100A8 / MRP8
Mouse
ELISA IHC IHC-P
Unconjugated
Anti-S100A8 / MRP8 Antibody (aa2-98, clone 63N13G5) LS-C359399
Immunohistochemistry-Paraffin: S100A8 Antibody (63N13G5) - Formalin-fixed, paraffin-embedded mouse spleen stained with S100A8 antibody (5 ug/ml), peroxidase-conjugate and DAB chromogen.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Western Blot: S100A8 Antibody (63N13G5) - Analysis of S100A8 in 1) recombinant protein 2) mouse spleen and 3) mouse lung lysate using S1008A antibody at 1 ug/ml. goat anti-rat Ig HRP secondary antibody.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

Rat Monoclonal [clone 63N13G5] (IgG2b,l) to Mouse S100A8 / MRP8
Mouse
IHC IHC-P WB
Unconjugated

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If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).


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