S100A8 / MRP8

S100 calcium binding protein A8

S100A8 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It can induce neutrophil chemotaxis and adhesion. Predominantly found as calprotectin (S100A8/A9) which has a wide plethora of intra- and extracellular functions. The intracellular functions include: facilitating leukocyte arachidonic acid trafficking and metabolism, modulation of the tubulin-dependent cytoskeleton during migration of phagocytes and activation of the neutrophilic NADPH-oxidase. Activates NADPH-oxidase by facilitating the enzyme complex assembly at the cell membrane, transferring arachidonic acid, an essential cofactor, to the enzyme complex and S100A8 contributes to the enzyme assembly by directly binding to NCF2/P67PHOX. The extracellular functions involve proinfammatory, antimicrobial, oxidant-scavenging and apoptosis-inducing activities. Its proinflammatory activity includes recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to pattern recognition receptors such as Toll-like receptor 4 (TLR4) and receptor for advanced glycation endproducts (AGER). Binding to TLR4 and AGER activates the MAP-kinase and NF-kappa-B signaling pathways resulting in the amplification of the proinflammatory cascade. Has antimicrobial activity towards bacteria and fungi and exerts its antimicrobial activity probably via chelation of Zn2+ which is essential for microbial growth. Can induce cell death via autophagy and apoptosis and this occurs through the cross-talk of mitochondria and lysosomes via reactive oxygen species (ROS) and the process involves BNIP3. Can regulate neutrophil number and apoptosis by an anti-apoptotic effect; regulates cell survival via ITGAM/ITGB and TLR4 and a signaling mechanism involving MEK-ERK. Its role as an oxidant scavenger has a protective role in preventing exaggerated tissue damage by scavenging oxidants. Can act as a potent amplifier of inflammation in autoimmunity as well as in cancer development and tumor spread.

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Products

ELISA Kits (30)

Type

Competitive EIA (2)

Custom (2)

Development Kit (2)

Sandwich (22)

Sandwich CLIA (2)

Target

S100A8 / MRP8 (30)

Reactivity

Human (8)

Mouse (10)

Rat (4)

Bovine (1)

Chicken (1)

Guinea pig (1)

Monkey (1)

Porcine (1)

Rabbit (1)

Sheep (1)

Product Group

DevKit DuoPlus (2)

Format

12 x 8-Well Microstrips (2)

96-Well Microplate (1)

96-Well Strip Plate (25)

Antibody Pair and Standard (2)

Publications

No (30)

Sample Type

Cell Culture Supernatants (8)

Cell Lysates (7)

Cell Supernatant (1)

Plasma (24)

Serum (24)

Tissue Homogenates (9)

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Human S100A8 / MRP8 (Sandwich ELISA) ELISA Kit - LS-F4982

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

15.63 - 1000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$685

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Mouse S100A8 / MRP8 (Sandwich ELISA) ELISA Kit - LS-F6832

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

7.81 - 500 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$818

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Rat S100A8 / MRP8 (Sandwich ELISA) ELISA Kit - LS-F8024

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$741

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Mouse S100A8 / MRP8 (Sandwich ELISA) ELISA Kit - LS-F12538

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$783

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Human S100A8 / MRP8 (Sandwich ELISA) ELISA Kit - LS-F12537

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$783

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Mouse S100A8 / MRP8 (CLIA) ELISA Kit - LS-F31037

Type:

Sandwich CLIA

Format:

12 x 8-Well Microstrips

Reactivity:

Mouse

Range:

125 - 8000 pg/ml

Detection:

Chemiluminescent

Sample Types:

Plasma, Serum

Price:

1 Plate/$728

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Monkey S100A8 / MRP8 (Sandwich ELISA) ELISA Kit - LS-F47849

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Monkey

Range:

0.625 - 40 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$728

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DevKit DuoPlus Human S100A8 / MRP8 ELISA Development Kit - LS-F71467

Type:

Development Kit

Format:

Antibody Pair and Standard

Reactivity:

Human

Range:

31.2 - 2000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates

Price:

500 Wells/$1,089; 1000 Wells/$1,589

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Chicken S100A8 / MRP8 (Sandwich ELISA) ELISA Kit - LS-F47847

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Chicken

Range:

0.625 - 40 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$728

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Guinea pig S100A8 / MRP8 (Sandwich ELISA) ELISA Kit - LS-F47848

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Guinea pig

Range:

62.5 - 4000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$728

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Rabbit S100A8 / MRP8 (Sandwich ELISA) ELISA Kit - LS-F47850

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rabbit

Range:

31.25 - 2000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$728

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Sheep S100A8 / MRP8 (Sandwich ELISA) ELISA Kit - LS-F47851

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Sheep

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$760

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Human S100A8 / MRP8 (Sandwich ELISA) ELISA Kit - LS-F39690

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

31.2 - 2000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Cell Lysates, Plasma, Serum

Price:

1 Plate/$795

Select

Mouse S100A8 / MRP8 (Sandwich ELISA) ELISA Kit - LS-F39691

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

31.2 - 2000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Cell Lysates, Plasma, Serum

Price:

1 Plate/$636

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Mouse S100A8 / MRP8 (Sandwich ELISA) ELISA Kit - LS-F74764

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

62.5 - 4000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Supernatant, Plasma, Serum

Price:

1 Plate/$598

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DevKit DuoPlus Mouse S100A8 / MRP8 ELISA Development Kit - LS-F71847

Type:

Development Kit

Format:

Antibody Pair and Standard

Reactivity:

Mouse

Range:

15.62 - 1000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates

Price:

500 Wells/$1,254; 1000 Wells/$1,867

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Mouse S100A8 / MRP8 (Sandwich ELISA) ELISA Kit - LS-F53369

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.625 - 40 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$958

Select

Human S100A8 / MRP8 (Sandwich ELISA) ELISA Kit - LS-F22582

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

0.625 - 40 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$651

Select

Rat S100A8 / MRP8 (Custom ELISA) ELISA Kit - LS-F18540

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Rat

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$783

Select

Bovine S100A8 / MRP8 (Custom ELISA) ELISA Kit - LS-F18541

Type:

Custom

Format:

96-Well Strip Plate

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$783

Select

Mouse S100A8 / MRP8 (Sandwich ELISA) ELISA Kit - LS-F34501

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.625 - 40 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

Select

Mouse S100A8 / MRP8 (Sandwich ELISA) ELISA Kit - LS-F31746

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

31.2 - 2000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Plasma, Serum

Price:

1 Plate/$717

Select

Human S100A8 / MRP8 (CLIA) ELISA Kit - LS-F29834

Type:

Sandwich CLIA

Format:

12 x 8-Well Microstrips

Reactivity:

Human

Range:

125 - 8000 pg/ml

Detection:

Chemiluminescent

Sample Types:

Plasma, Serum

Price:

1 Plate/$728

Select

Mouse S100A8 / MRP8 (Competitive EIA) ELISA Kit - LS-F28587

Type:

Competitive EIA

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

2.5 - 50 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$913

Select

Human S100A8 / MRP8 (Sandwich ELISA) ELISA Kit - LS-F27207

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.5 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$913

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