S100A12

S100 calcium binding protein A12

S100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. Its proinflammatory activity involves recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to receptor for advanced glycation endproducts (AGER). Binding to AGER activates the MAP-kinase and NF-kappa-B signaling pathways leading to production of proinflammatory cytokines and up-regulation of cell adhesion molecules ICAM1 and VCAM1. Acts as a monocyte and mast cell chemoattractant. Can stimulate mast cell degranulation and activation which generates chemokines, histamine and cytokines inducing further leukocyte recruitment to the sites of inflammation. Can inhibit the activity of matrix metalloproteinases; MMP2, MMP3 and MMP9 by chelating Zn2+ from their active sites. Possesses filariacidal and filariastatic activity. Calcitermin possesses antifungal activity against C.albicans and is also active against E.coli and P.aeruginosa but not L.monocytogenes and S.aureus.

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Proteins (14)

Type

Over-Expression Lysate (2)

Recombinant (12)

Target

S100A12 (14)

Publications

No (14)

Tag

GST (2)

GST, N-terminus (1)

His (1)

His, N-Terminal (1)

His-S (2)

His-T7 (1)

Myc-DDK (Flag) (3)

Species

Bovine (1)

Human (10)

Pig (1)

Rabbit (1)

Source

293T Cells (1)

E. coli (9)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (4)

Low Endotoxin Level

Low endotoxin level (2)

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Human S100A12 Protein (Recombinant) (Met1-Glu92) - LS-G39144

Source:

E. coli

Tag:

None

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

10.6kD

Price:

10 µg/$281; 50 µg/$395; 500 µg/$1,585; 1 mg/$2,157

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Human S100A12 Protein (Recombinant GST) (Full Length) - LS-G30307

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

37 kDa

Price:

10 µg/$479; 25 µg/$670

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Human S100A12 Protein (Recombinant GST) (Full Length) - LS-G30308

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

35.75 kDa

Price:

10 µg/$479; 25 µg/$670

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Bovine S100A12 Protein (Recombinant His-T7) (aa2-92) - LS-G24200

Source:

E. coli

Tag:

His-T7

Molecular Weight:

14.2 kDa

Price:

10 µg/$276; 50 µg/$412; 100 µg/$657; 200 µg/$822; 1 mg/$1,905; 500 µg/$1,455; 5 mg/$2,871; 2 mg/$2,090

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Rabbit S100A12 Protein (Recombinant His-S) (aa2-92) - LS-G24202

Source:

E. coli

Tag:

His-S

Molecular Weight:

14.2 kDa

Price:

10 µg/$289; 50 µg/$492; 100 µg/$785; 200 µg/$982; 1 mg/$2,119; 500 µg/$1,646; 5 mg/$3,431; 2 mg/$2,309

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Pig S100A12 Protein (Recombinant His-S) (aa2-92) - LS-G24201

Source:

E. coli

Tag:

His-S

Molecular Weight:

14.3 kDa

Price:

10 µg/$286; 50 µg/$472; 100 µg/$752; 200 µg/$942; 1 mg/$2,069; 500 µg/$1,600; 5 mg/$3,291; 2 mg/$2,257

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Human S100A12 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G74933

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

10.4 kDa

Price:

20 µg/$150

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Human S100A12 Protein (Recombinant GST, N-terminus) - LS-G56505

Source:

E. coli

Tag:

GST, N-terminus

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human S100A12 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65138

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

10.4 kDa

Price:

20 µg/$1,107

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S100A12 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G100607

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

10.4 kDa

Price:

100 µg/$494

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Human S100A12 Protein (Recombinant) (Met1-Glu92) - LS-G97845

Source:

E. coli

Tag:

None

Molecular Weight:

10.6 kDa

Price:

100 µg/$721

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Human S100A12 Protein (Recombinant His, N-Terminal) (Thr2-Glu92) - LS-G96771

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

13 kDa

Price:

10 µg/$265; 100 µg/$365; 250 µg/$518; 50 µg/$315

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Human S100A12 Protein (Recombinant) (Met1-Glu92) - LS-G139335

Source:

E. coli

Tag:

None

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

10.6 kDa

Price:

10 µg/$281; 50 µg/$389

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Human S100A12 Protein (Recombinant His) (aa1-92) - LS-G13316

Source:

E. coli

Tag:

His

Molecular Weight:

11.8 kDa

Price:

10 µg/$268; 50 µg/$362; 100 µg/$577; 200 µg/$722; 1 mg/$1,755; 500 µg/$1,325; 5 mg/$2,708; 2 mg/$1,934

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