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RYR1 / RYR

ryanodine receptor 1 (skeletal)

Calcium channel that mediates the release of Ca2+ from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules. Repeated very high-level exercise increases the open probability of the channel and leads to Ca2+ leaking into the cytoplasm. Can also mediate the release of Ca2+ from intracellular stores in neurons, and may thereby promote prolonged Ca2+ signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. Required for normal heart morphogenesis, skin development and ossification during embryogenesis.

Gene Name: ryanodine receptor 1 (skeletal)
Family/Subfamily: Ion Channel , Ryanodine receptor
Synonyms: RYR1, CCO, Central core disease of muscle, MHS, RYDR, Ryanodine receptor type 1, RYR-1, SKRR, Type 1 ryanodine receptor, Ryanodine receptor 1, Ryanodine receptor type1, MHS1, RyR, Type 1-like ryanodine receptor
Target Sequences: NM_000540 NP_000531.2 P21817

Publications (1)

1
Inositol 1,4,5-trisphosphate (IP3)-dependent Ca2+ signaling mediates delayed myogenesis in Duchenne muscular dystrophy fetal muscle. Farini A, Sitzia C, Cassinelli L, Colleoni F, Parolini D, Giovanella U, Maciotta S, Colombo A, Meregalli M, Torrente Y. Development (Cambridge, England). 2016 February;143:658-69. (Human) [Full Text Article] [PubMed:26884398] Related Antibodies: LS-C153542.

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Products
Antibodies (9)
Primary (9)
RYR1 / RYR (9)
Human (9)
Mouse (1)
Rat (1)
IHC (1)
WB (9)
ELISA (8)
ICC (1)
Peptide-ELISA (1)
rabbit (9)
IgG (6)
polyclonal pc (9)
Biotin Conjugated (1)
FITC Conjugated (1)
HRP Conjugated (1)
Unconjugated (6)
C-Terminus (3)
aa1-534 (1)
No (8)
Yes (1)
RYR1 / RYR Antibody - Western blot analysis of Mouse brain tissue, using RYR1 Polyclonal Antibody at dilution of 1:400.
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RYR1 / RYR Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
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RYR1 / RYR Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
ELISA, IHC, WB
Unconjugated
50 µg/$440; 100 µg/$480
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RYR1 / RYR Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
ELISA, WB
Unconjugated
0.1 mg/$379
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RYR1 / RYR Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
ELISA, ICC, WB
Unconjugated
100 µl/$440; 200 µl/$468
RYR1 / RYR Antibody - Immunofluorescent analysis of HepG2 cells using RYR1 Antibody at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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RYR1 / RYR Rabbit anti-Human Polyclonal (aa1-534) Antibody
Human
ELISA, WB
Unconjugated
50 µg/$294; 100 µg/$360
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RYR1 / RYR Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA, WB
HRP Conjugated
50 µg/$294; 100 µg/$360
Select
RYR1 / RYR Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
50 µg/$294; 100 µg/$360
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RYR1 / RYR Rabbit anti-Human Polyclonal (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
50 µg/$294; 100 µg/$360
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RYR1 / RYR Rabbit anti-Human Polyclonal Antibody
Human
Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
Viewing 1-9 of 9 product results


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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).