RXTA / RXR-Alpha

retinoid X receptor, alpha

Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid. RXRA serves as a common heterodimeric partner for a number of nuclear receptors. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. The RXRA/PPARA heterodimer is required for PPARA transcriptional activity on fatty acid oxidation genes such as ACOX1 and the P450 system genes.

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Products

Proteins (7)

Type

Over-Expression Lysate (2)

Recombinant (5)

Target

RXTA / RXR-Alpha (7)

Publications

No (7)

Tag

GST (1)

GST, N-terminus (2)

Myc-DDK (Flag) (3)

Species

Human (6)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (2)

Wheat Germ Extract (3)

Purification

Purified (1)

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Human RXTA / RXR-Alpha Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G66870

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

50.6 kDa

Price:

20 µg/$1,107

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Human RXTA / RXR-Alpha Protein (Recombinant) - LS-G3545

Source:

E. coli

Tag:

None

Price:

100 µg/$317; 500 µg/$526; 20 µg/$245

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Human RXTA / RXR-Alpha Protein (Recombinant GST, N-terminus) (aa27-94) - LS-G60012

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human RXTA / RXR-Alpha Protein (Recombinant GST, N-terminus) (aa1-110) - LS-G60011

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human RXTA / RXR-Alpha Protein (Recombinant GST) (Full Length) - LS-G30296

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

43.89 kDa

Price:

2 µg/$439

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Human RXTA / RXR-Alpha Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G78634

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

50.6 kDa

Price:

20 µg/$150

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RXTA / RXR-Alpha Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99917

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

50.6 kDa

Price:

100 µg/$494

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