RWDD3

RWD domain containing 3

Enhancer of SUMO conjugation. Via its interaction with UBE2I/UBC9, increases SUMO conjugation to proteins by promoting the: binding of E1 and E2 enzymes, thioester linkage between SUMO and UBE2I/UBC9 and transfer of SUMO to specific target proteins which include HIF1A, PIAS, NFKBIA, NR3C1 and TOP1. Isoform 1 and isoform 2 positively regulate the NF-kappa-B signaling pathway by enhancing the sumoylation of NF-kappa-B inhibitor alpha (NFKBIA), promoting its stabilization which consequently leads to an increased inhibition of NF-kappa-B transcriptional activity. Isoform 1 and isoform 2 negatively regulate the hypoxia-inducible factor-1 alpha (HIF1A) signaling pathway by increasing the sumoylation of HIF1A, promoting its stabilization, transcriptional activity and the expression of its target gene VEGFA during hypoxia. Isoform 2 promotes the sumoylation and transcriptional activity of the glucocorticoid receptor NR3C1 and enhances the interaction of SUMO1 and NR3C1 with UBE2I/UBC9. Has no effect on ubiquitination.

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Products

Proteins (6)

Type

Over-Expression Lysate (4)

Recombinant (2)

Target

RWDD3 (6)

Publications

No (6)

Tag

GST (1)

Myc-DDK (Flag) (5)

Species

Human (4)

Source

293T Cells (2)

HEK 293 Cells (3)

Wheat Germ Extract (1)

Purification

Purified (1)

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RWDD3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G124743

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

21.9 kDa

Price:

100 µg/$494

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Human RWDD3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G90134

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

21.9 kDa

Price:

20 µg/$150

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Human RWDD3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G90135

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

30.3 kDa

Price:

20 µg/$150

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RWDD3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G113189

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

30.3 kDa

Price:

100 µg/$494

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Human RWDD3 Protein (Recombinant GST) (Full Length) - LS-G33043

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

48.5 kDa

Price:

10 µg/$479; 25 µg/$670

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Human RWDD3 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G71584

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

21.9 kDa

Price:

20 µg/$1,107

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