RUNX1T1 / ETO is a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Alternative splicing results in multiple transcript variants.
|Gene Name:||runt-related transcription factor 1; translocated to, 1 (cyclin D-related)|
|Synonyms:||RUNX1T1, AML1T1, CBFA2T1, CDR, Eight twenty one protein, Cyclin-D-related protein, ETO, MTG8, Protein CBFA2T1, Protein ETO, ZMYND2, Protein MTG8|
|Target Sequences:||NM_004349 NP_004340.1 Q06455|
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