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RTN2 / Reticulon 2 belongs to the family of reticulon encoding genes. Reticulons are necessary for proper generation of tubular endoplasmic reticulum and likely play a role in intracellular vesicular transport. Alternatively spliced transcript variants encoding different isoforms have been identified. Mutations at this locus have been associated with autosomal dominant spastic paraplegia-12.
Gene Name: | reticulon 2 |
Family/Subfamily: | Reticulon |
Synonyms: | RTN2, NSPLI, NSP2, Reticulon 2, SPG12, NSP-like protein 1, NSP-like protein I, NSPL1, Reticulon-2 |
Target Sequences: | NM_005619 NP_005610.1 O75298 |
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