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RTCB / C22orf28

RNA 2',3'-cyclic phosphate and 5'-OH ligase

Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs.

Gene Name:	RNA 2',3'-cyclic phosphate and 5'-OH ligase
Synonyms:	RTCB, Ankyrin repeat domain 54, C22orf28, DJ149A16.6, HSPC117, FAAP, RP1-149A16.6
Target Sequences:	NM_014306 NP_055121.1 Q9Y3I0

Publications (2)

hCLE/RTRAF-HSPC117-DDX1-FAM98B: A New Cap-Binding Complex That Activates mRNA Translation. Pazo A, Pérez-González A, Oliveros JC, Huarte M, Chavez JP, Nieto A. Frontiers in physiology. 2019 February;10:92. [Full Text Article] [PubMed:30833903] [PMC:PMC6388641]

hCLE/C14orf166 associates with DDX1-HSPC117-FAM98B in a novel transcription-dependent shuttling RNA-transporting complex. P[Character e9]rez-Gonz[Character e1]lez A, Pazo A, Navajas R, Ciordia S, Rodriguez-Frandsen A, Nieto A. PloS one. 2014 9:e90957. (WB; Human) [Full Text Article] [PubMed:24608264] [PMC:PMC3946611] Related Antibodies: LS-B10474.

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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