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RSPO1 / RSPO

R-spondin 1

Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination.

Gene Name: R-spondin 1
Synonyms: RSPO1, CRISTIN3, HRspo1, R-spondin 1, Roof plate-specific spondin-1, RSPONDIN, RSPO, R-spondin-1, R-spondin1, R-spondin homolog, RP11-566C13.1
Target Sequences: Q2MKA7 Q2MKA7

☰ Filters
Products
Antibodies (51)
Primary (51)
RSPO1 / RSPO (51)
Human (26)
Mouse (12)
Rat (19)
IHC (7)
IHC-P (5)
WB (46)
ELISA (6)
IF (1)
Neut (1)
Peptide-ELISA (1)
rabbit (39)
mouse (11)
sheep (1)
Product Group
IHCPlus (2)
IgG (6)
IgG1 (7)
IgG2a (2)
IgG2b (2)
monoclonal mc (11)
polyclonal pc (40)
7A6 (2)
OTI11A9 (2)
OTI1C3 (2)
OTI2B11 (2)
OTI2F10 (2)
APC (4)
APC Conjugated (4)
Biotin Conjugated (4)
Carrier-free (4)
Cy3 Conjugated (4)
Cy7 Conjugated (4)
FITC Conjugated (4)
HRP Conjugated (4)
PE Conjugated (4)
Preservative Free (1)
Unconjugated (23)
aa21-135 (24)
aa21-263 (9)
aa136-262 (8)
aa206-240 (1)
aa31-263 (1)
No (51)
RSPO1 / RSPO Antibody - Anti-RSPO1 antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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RSPO1 / RSPO Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
0.05 mg/$460
RSPO1 / RSPO Antibody - Immunohistochemistry of paraffin-embedded human colon cancer using antibody at 1:100 dilution.
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RSPO1 / RSPO Rabbit anti-Human Polyclonal (aa21-263) Antibody
Human
ELISA, IHC-P
Unconjugated
50 µl/$294; 100 µl/$360
RSPO1 / RSPO Antibody - Western blot of recombinant RSPO1 / RSPO.
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RSPO1 / RSPO Rabbit anti-Human Polyclonal (aa21-135) Antibody
Human
WB
Unconjugated
100 µl/$319; 200 µl/$365; 500 µl/$519; 1 ml/$597; 2 ml/$826; 5 ml/$1,352
RSPO1 / RSPO Antibody - Western blot of recombinant RSPO1 / RSPO.
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RSPO1 / RSPO Rabbit anti-Human Polyclonal (aa21-135) (HRP) Antibody
Human
WB
HRP Conjugated
100 µl/$351; 200 µl/$411; 500 µl/$618; 1 ml/$774; 2 ml/$1,010; 5 ml/$1,757
RSPO1 / RSPO Antibody - Human Small Intestine, Vessels: Formalin-Fixed, Paraffin-Embedded (FFPE)
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RSPO1 / RSPO Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
RSPO1 / RSPO Antibody - Western blot of recombinant RSPO1 / RSPO.
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RSPO1 / RSPO Rabbit anti-Mouse Polyclonal (aa21-135) Antibody
Mouse
WB
Unconjugated
100 µl/$321; 200 µl/$369; 500 µl/$527; 1 ml/$611; 2 ml/$842; 5 ml/$1,387
RSPO1 / RSPO Antibody - Western blot of recombinant RSPO1 / RSPO.
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RSPO1 / RSPO Rabbit anti-Mouse Polyclonal (aa21-135) (Biotin) Antibody
Mouse
WB
Biotin Conjugated
100 µl/$333; 200 µl/$385; 500 µl/$559; 1 ml/$671; 2 ml/$907; 5 ml/$1,525
RSPO1 / RSPO Antibody - Western blot of recombinant RSPO1 / RSPO.
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RSPO1 / RSPO Rabbit anti-Mouse Polyclonal (aa21-135) (APC) Antibody
Mouse
WB
APC Conjugated
100 µl/$432; 200 µl/$527; 500 µl/$934; 1 ml/$1,104; 2 ml/$1,479; 5 ml/$2,773
RSPO1 / RSPO Antibody - Western blot of recombinant RSPO1 / RSPO.
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RSPO1 / RSPO Rabbit anti-Mouse Polyclonal (aa21-135) (Cy3) Antibody
Mouse
WB
Cy3 Conjugated
100 µl/$432; 200 µl/$527; 500 µl/$934; 1 ml/$1,104; 2 ml/$1,479; 5 ml/$2,773
RSPO1 / RSPO Antibody - IHC of paraffin-embedded Human lymph node tissue using anti-RSPO1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).
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RSPO1 / RSPO Mouse anti-Human Monoclonal (aa21-263) (OTI11A9) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
RSPO1 / RSPO Antibody - Immunohistochemical staining of paraffin-embedded Human lymph node tissue within the normal limits using anti-RSPO1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min,
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RSPO1 / RSPO Mouse anti-Human Monoclonal (aa21-263) (Carrier-free) (OTI11A9) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
RSPO1 / RSPO Antibody - Western Blot (WB) analysis using R-Spondin Monoclonal Antibody against recombinant R-spondin1 protein (1) and R-spondin1(aa21-263)-hIgGFc transfected HEK293 cell lysate(2).
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RSPO1 / RSPO Mouse anti-Human Monoclonal Antibody
Human
ELISA, WB
Unconjugated
50 µg/$332; 100 µg/$404; 200 µg/$505
RSPO1 / RSPO Antibody - All lanes: Anti-RSPO1 Antibody (C-Term) at 1:2000 dilution. Lane 1: HL-60 whole cell lysate. Lane 2: Jurkat whole cell lysate. Lane 3: K562 whole cell lysate Lysates/proteins at 20 ug per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1:10000 dilution. Predicted band size: 29 kDa. Blocking/Dilution buffer: 5% NFDM/TBST.
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RSPO1 / RSPO Rabbit anti-Human Polyclonal (aa206-240) Antibody
Human
Peptide-ELISA, WB
Unconjugated
200 µl/$393
RSPO1 / RSPO Antibody - IHC of paraffin-embedded Human colon tissue using anti-RSPO1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).
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RSPO1 / RSPO Mouse anti-Human Monoclonal (aa21-263) (OTI1C3) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
RSPO1 / RSPO Antibody - Immunohistochemical staining of paraffin-embedded Human colon tissue within the normal limits using anti-RSPO1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min,
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RSPO1 / RSPO Mouse anti-Human Monoclonal (aa21-263) (Carrier-free) (OTI1C3) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
RSPO1 / RSPO Antibody - Western blot using R-spondin1 mouse monoclonal antibody against recombinant R-spondin1 protein (1) and R-spondin1(aa21-263)-hIgGFc transfected HEK293 cell lysate(2).
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RSPO1 / RSPO Mouse anti-Human Monoclonal (7A6) Antibody
Human
ELISA, WB
Unconjugated
100 µl/$435
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RSPO1 / RSPO Rabbit anti-Mouse Polyclonal Antibody
Mouse
ELISA
Unconjugated
100 µl/$412
RSPO1 / RSPO Antibody - Immunohistochemistry of paraffin-embedded Rat lung using RSPO1 Polyclonal Antibody at dilution of 1:100 (40x lens).
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RSPO1 / RSPO Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
RSPO1 / RSPO Antibody - HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY RSPO1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-RSPO1.
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RSPO1 / RSPO Mouse anti-Human Monoclonal (aa21-263) (OTI2F10) Antibody
Human
WB
Unconjugated
100 µl/$434
RSPO1 / RSPO Antibody - HEK293T cells were transfected with the pCMV6-ENTRY control. (Left lane) or pCMV6-ENTRY RSPO1. (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates. (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-RSPO1.
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RSPO1 / RSPO Mouse anti-Human Monoclonal (aa21-263) (Carrier-free) (OTI2F10) Antibody
Human
WB
Unconjugated, Carrier-free
100 µg/$511
RSPO1 / RSPO Antibody - HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY RSPO1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-RSPO1.
Select
RSPO1 / RSPO Mouse anti-Human Monoclonal (aa21-263) (OTI2B11) Antibody
Human
WB
Unconjugated
100 µl/$434
RSPO1 / RSPO Antibody - HEK293T cells were transfected with the pCMV6-ENTRY control. (Left lane) or pCMV6-ENTRY RSPO1. (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates. (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-RSPO1.
Select
RSPO1 / RSPO Mouse anti-Human Monoclonal (aa21-263) (Carrier-free) (OTI2B11) Antibody
Human
WB
Unconjugated, Carrier-free
100 µg/$511
RSPO1 / RSPO Antibody - RSPO1 Antibody in Western Blot (WB)
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RSPO1 / RSPO Mouse anti-Human Monoclonal (7A6) Antibody
Human
WB
Unconjugated
100 µl/$518
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RSPO1 / RSPO Rabbit anti-Human Polyclonal (Preservative Free) Antibody
Human
ELISA
Unconjugated, Preservative Free
100 µl/$412
RSPO1 / RSPO Antibody - Western blot of recombinant RSPO1 / RSPO.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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RSPO1 / RSPO Rabbit anti-Rat Polyclonal (aa136-262) Antibody
Rat
WB
Unconjugated
100 µl/$328; 200 µl/$378; 500 µl/$545; 1 ml/$645; 2 ml/$879; 5 ml/$1,464
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).