LSBio
LSBio
Products
Services
Research Areas
Resources
Contact Us
Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

LSBio
2401 Fourth Avenue Suite 900
Seattle WA 98121

Phone: 866-819-4732 (Toll Free North America)
206-374-1102 (International)

Fax: 866-206-6909 (Toll Free North America)
206-577-4565 (International)

How to Buy - Details about how to buy our products.

Orders@LSBio.com - To submit a new order.

Customer.Support@LSBio.com - To submit questions about existing orders, pricing, availability, bulk quotes, proforma invoice requests, or other billing issues.

Technical.Support@LSBio.com - To request technical information requests about an LSBio product or its application.

Sales@LSBio.com - To request information about fee-for-service contract IHC studies, IHC reports, distribution agreements, or general business development.

Worldwide Distributors List - To find your local distributor if you're not within the United States.
Products
Services
Research Areas
Resources
Contact Us

RRM2B / P53R2

ribonucleotide reductase M2 B (TP53 inducible)

The p53 tumor-suppressor gene integrates numerous signals that control cell life and death. Several novel molecules involved in p53 signaling, including p53R2, Chk2, p53AIP1, Noxa, PIDD, and PID/MTA2, were recently discovered. p53R2 is a p53 inducible gene that contains a p53 binding sequence and encodes a subunit of the enzyme ribonucleotide reductase. p53R2 is induced by the reagents, ultraviolet and g-irradiation that cause DNA damages. The product of p53R2 gene is directly involved in the p53 checkpoint for repair of damaged DNA. The isoform of the p53 family member p73 also induces p53R2 expression. p53R2 is an important target of p53 for tumor suppression.

Gene Name: ribonucleotide reductase M2 B (TP53 inducible)
Family/Subfamily: RIBONUCLEOTIDE REDUCTASE , not assigned-RIBONUCLEOTIDE REDUCTASE
Synonyms: RRM2B, MTDPS8A, MTDPS8B, p53R2, PEOA5
Target Sequences: NM_015713 NP_056528.2 Q7LG56

Publications (3)

1
Ribonucleotide reductase small subunit M2B prognoses better survival in colorectal cancer. Liu X, Lai L, Wang X, Xue L, Leora S, Wu J, Hu S, Zhang K, Kuo ML, Zhou L, Zhang H, Wang Y, Wang Y, Zhou B, Nelson RA, Zheng S, Zhang S, Chu P, Yen Y. Cancer research. 2011 71:3202-13. [PubMed:21415168] [PMC:PMC3085570] Related Antibodies: LS-C154254.
2
Ribonucleotide reductase subunit p53R2 regulates mitochondria homeostasis and function in KB and PC-3 cancer cells. Wang X, Liu X, Xue L, Zhang K, Kuo ML, Hu S, Zhou B, Ann D, Zhang S, Yen Y. Biochemical and biophysical research communications. 2011 410:102-7. [PubMed:21640705] [PMC:PMC3180957] Related Antibodies: LS-C154254.
3
RRM2B suppresses activation of the oxidative stress pathway and is up-regulated by p53 during senescence. Kuo ML, Sy AJ, Xue L, Chi M, Lee MT, Yen T, Chiang MI, Chang L, Chu P, Yen Y. Scientific reports. 2012 2:822. [PubMed:23139867] [PMC:PMC3492868] Related Antibodies: LS-C154254.

Filtered by: None
Type
Over-Expression Lysate (5)
Recombinant (4)
Target
RRM2B / P53R2 (9)
Tag
GST,N-terminus (2)
His (1)
Myc + DDK (6)
Species
Human (6)
Source
293T Cells (2)
E. coli (2)
HEK 293 Cells (4)
Wheat Germ Extract (1)
Purification
Purified (2)
Publications
No (9)
Showing 1-9 of 9 results

Human RRM2B / P53R2 Protein (Recombinant GST,N-terminus) (aa3-84) - LS-G62360
Wheat Germ Extract
GST,N-terminus
10µg  $425.00; 25µg  $590.00
12.5% SDS-PAGE Stained with Coomassie Blue.

Human RRM2B / P53R2 Protein (Recombinant His) (Met1-Phe351) - LS-G97838
E. coli
His
42.6 kDa
50µg  $680.00; 100µg  $1,080.00

Human RRM2B / P53R2 Protein (Recombinant Myc + DDK) (Full Length) - LS-G69679
HEK 293 Cells
Myc + DDK
40.6 kDa
20µg  $890.00
Purified recombinant protein RRM2B was analyzed by SDS-PAGE gel and Coomassie Blue Staining

RRM2B / P53R2 Protein (Over-Expression Lysate Myc + DDK) (Full Length) - LS-G113072
HEK 293 Cells
Myc + DDK
40.6 kDa
100µg  $365.00
Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate

RRM2B / P53R2 Protein (Over-Expression Lysate Myc + DDK) (Full Length) - LS-G129585
HEK 293 Cells
Myc + DDK
35 kDa
100µg  $345.00

RRM2B / P53R2 Protein (Over-Expression Lysate Myc + DDK) (Full Length) - LS-G129791
HEK 293 Cells
Myc + DDK
49.2 kDa
100µg  $365.00
Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate

Human RRM2B / P53R2 Protein (Over-Expression Lysate Myc + DDK) (Full Length) - LS-G85250
293T Cells
Myc + DDK
49.2 kDa
20µg  $195.00
Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate

Human RRM2B / P53R2 Protein (Over-Expression Lysate Myc + DDK) (Full Length) - LS-G85252
293T Cells
Myc + DDK
40.6 kDa
20µg  $195.00
Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate

Human RRM2B / P53R2 Protein (Recombinant GST,N-terminus) (aa1-351) - LS-G56786
E. coli
GST,N-terminus
1mg  $1,845.00; 500µg  $1,185.00; 200µg  $710.00; 100µg  $445.00; 50µg  $325.00; 10µg  $275.00
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Showing 1-9 of 9 results

Selected:

If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

Get Social With Us!
Follow us on Facebook Follow us on LinkedIn
Copyright © 2019 LifeSpan BioSciences, Inc. All Rights Reserved Privacy Policy