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RRM2B / P53R2
ribonucleotide reductase M2 B (TP53 inducible)
The p53 tumor-suppressor gene integrates numerous signals that control cell life and death. Several novel molecules involved in p53 signaling, including p53R2, Chk2, p53AIP1, Noxa, PIDD, and PID/MTA2, were recently discovered. p53R2 is a p53 inducible gene that contains a p53 binding sequence and encodes a subunit of the enzyme ribonucleotide reductase. p53R2 is induced by the reagents, ultraviolet and g-irradiation that cause DNA damages. The product of p53R2 gene is directly involved in the p53 checkpoint for repair of damaged DNA. The isoform of the p53 family member p73 also induces p53R2 expression. p53R2 is an important target of p53 for tumor suppression.
| Gene Name: | ribonucleotide reductase M2 B (TP53 inducible) |
| Family/Subfamily: | RIBONUCLEOTIDE REDUCTASE , not assigned-RIBONUCLEOTIDE REDUCTASE |
| Synonyms: | RRM2B, MTDPS8A, MTDPS8B, p53R2, PEOA5 |
| Target Sequences: | NM_015713 NP_056528.2 Q7LG56 |
Publications (3)
1
Ribonucleotide reductase small subunit M2B prognoses better survival in colorectal cancer. Liu X, Lai L, Wang X, Xue L, Leora S, Wu J, Hu S, Zhang K, Kuo ML, Zhou L, Zhang H, Wang Y, Wang Y, Zhou B, Nelson RA, Zheng S, Zhang S, Chu P, Yen Y. Cancer research. 2011 71:3202-13.
[PubMed:21415168]
[PMC:PMC3085570]
Related Antibodies: LS-C154254.
2
Ribonucleotide reductase subunit p53R2 regulates mitochondria homeostasis and function in KB and PC-3 cancer cells. Wang X, Liu X, Xue L, Zhang K, Kuo ML, Hu S, Zhou B, Ann D, Zhang S, Yen Y. Biochemical and biophysical research communications. 2011 410:102-7.
[PubMed:21640705]
[PMC:PMC3180957]
Related Antibodies: LS-C154254.
3
RRM2B suppresses activation of the oxidative stress pathway and is up-regulated by p53 during senescence. Kuo ML, Sy AJ, Xue L, Chi M, Lee MT, Yen T, Chiang MI, Chang L, Chu P, Yen Y. Scientific reports. 2012 2:822.
[PubMed:23139867]
[PMC:PMC3492868]
Related Antibodies: LS-C154254.
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(31)
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RRM2B / P53R2
(31)
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(23)
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Publications
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(30)
Yes
(1)
RRM2B / P53R2 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$567
RRM2B / P53R2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50 µg/$460
RRM2B / P53R2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC-P, WB
Unconjugated
50 µl/$460
RRM2B / P53R2 Rabbit anti-Human Polyclonal (aa318-332) Antibody
Xenopus, Chicken, Sheep, Bovine, Rabbit, Mouse, Rat, Pig, Horse, Bat, Human, Monkey
WB
Unconjugated
10 µg/$318; 100 µg/$470
RRM2B / P53R2 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
ELISA, IF, IHC, IP, WB
Unconjugated
25 µl/$304
RRM2B / P53R2 Rabbit anti-Human Polyclonal (aa1-351) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$294; 100 µl/$360
RRM2B / P53R2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
100 µl/$412
RRM2B / P53R2 Rabbit anti-Human Polyclonal (aa1-351) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$294; 100 µl/$360
RRM2B / P53R2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
RRM2B / P53R2 Mouse anti-Human Monoclonal Antibody
Human
ELISA, WB
Unconjugated
20 µl/$256; 100 µl/$412
RRM2B / P53R2 Rabbit anti-Human Polyclonal Antibody
Human
IHC, IHC-P
Unconjugated
100 µl/$412
RRM2B / P53R2 Rabbit anti-Human Polyclonal (aa128-157) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$734
RRM2B / P53R2 Rabbit anti-Human Polyclonal (aa128-157) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
200 µl/$952
RRM2B / P53R2 Rabbit anti-Human Polyclonal (aa128-157) (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
200 µl/$952
RRM2B / P53R2 Rabbit anti-Human Polyclonal (aa128-157) (APC) Antibody
Human
ELISA, WB
APC Conjugated
200 µl/$952
RRM2B / P53R2 Rabbit anti-Human Polyclonal (aa128-157) (Azide-free) (HRP) Antibody
Human
ELISA, WB
HRP Conjugated, Azide-free
200 µl/$952
RRM2B / P53R2 Rabbit anti-Human Polyclonal (aa128-157) (PE) Antibody
Human
ELISA, WB
PE Conjugated
200 µl/$952
RRM2B / P53R2 Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
RRM2B / P53R2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
100 µg/$357
RRM2B / P53R2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
RRM2B / P53R2 Mouse anti-Human Monoclonal (Preservative Free) (11) Antibody
Human
ELISA
Unconjugated, Preservative Free
20 µl/$256; 100 µl/$412
RRM2B / P53R2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA
Unconjugated
100 µl/$412
RRM2B / P53R2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA
Unconjugated
100 µl/$412
RRM2B / P53R2 Rabbit anti-Human Polyclonal (aa2-17) Antibody
Mouse, Rat, Human
WB
Unconjugated
100 µg/$522
RRM2B / P53R2 Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
100 µl/$412
Viewing 1-25
of 31
product results
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