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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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RRM2B / P53R2

ribonucleotide reductase M2 B (TP53 inducible)

The p53 tumor-suppressor gene integrates numerous signals that control cell life and death. Several novel molecules involved in p53 signaling, including p53R2, Chk2, p53AIP1, Noxa, PIDD, and PID/MTA2, were recently discovered. p53R2 is a p53 inducible gene that contains a p53 binding sequence and encodes a subunit of the enzyme ribonucleotide reductase. p53R2 is induced by the reagents, ultraviolet and g-irradiation that cause DNA damages. The product of p53R2 gene is directly involved in the p53 checkpoint for repair of damaged DNA. The isoform of the p53 family member p73 also induces p53R2 expression. p53R2 is an important target of p53 for tumor suppression.

Gene Name: ribonucleotide reductase M2 B (TP53 inducible)
Family/Subfamily: RIBONUCLEOTIDE REDUCTASE , not assigned-RIBONUCLEOTIDE REDUCTASE
Synonyms: RRM2B, MTDPS8A, MTDPS8B, p53R2, PEOA5
Target Sequences: NM_015713 NP_056528.2 Q7LG56

Publications (3)

1
Ribonucleotide reductase small subunit M2B prognoses better survival in colorectal cancer. Liu X, Lai L, Wang X, Xue L, Leora S, Wu J, Hu S, Zhang K, Kuo ML, Zhou L, Zhang H, Wang Y, Wang Y, Zhou B, Nelson RA, Zheng S, Zhang S, Chu P, Yen Y. Cancer research. 2011 71:3202-13. [PubMed:21415168] [PMC:PMC3085570] Related Antibodies: LS-C154254.
2
Ribonucleotide reductase subunit p53R2 regulates mitochondria homeostasis and function in KB and PC-3 cancer cells. Wang X, Liu X, Xue L, Zhang K, Kuo ML, Hu S, Zhou B, Ann D, Zhang S, Yen Y. Biochemical and biophysical research communications. 2011 410:102-7. [PubMed:21640705] [PMC:PMC3180957] Related Antibodies: LS-C154254.
3
RRM2B suppresses activation of the oxidative stress pathway and is up-regulated by p53 during senescence. Kuo ML, Sy AJ, Xue L, Chi M, Lee MT, Yen T, Chiang MI, Chang L, Chu P, Yen Y. Scientific reports. 2012 2:822. [PubMed:23139867] [PMC:PMC3492868] Related Antibodies: LS-C154254.

Filtered by: None
Target
RRM2B / P53R2 (29)
Reactivity
Human (29)
Mouse (11)
Rat (11)
Bat (5)
Bovine (5)
Chicken (1)
Chimpanzee (3)
Gibbon (3)
Horse (1)
Monkey (2)
Orangutan (3)
Pig (1)
Rabbit (5)
Sheep (1)
Xenopus (5)
Application
IHC (6)
IHC-P (5)
WB (26)
ELISA (17)
IF (3)
IP (1)
Host
rabbit (28)
mouse (1)
Isotype
IgG (16)
Clonality
monoclonal mc (1)
polyclonal pc (28)
Format
AP Conjugated (1)
APC Conjugated (1)
Azide-free (1)
Biotin Conjugated (2)
FITC Conjugated (2)
HRP Conjugated (2)
PE Conjugated (1)
Unconjugated (20)
Epitope
aa128-157 (8)
aa81-130 (4)
Internal (2)
aa1-351 (2)
N-Terminus (1)
aa2-17 (1)
aa318-332 (1)
Publications
No (28)
Yes (1)
Showing 1-25 of 29 results

RRM2B / P53R2 Antibody IHC-plus™ LS-B545
Rabbit Polyclonal (IgG) to Human RRM2B / P53R2
Mouse, Rat, Human
ELISA IF IHC IHC-P WB
Unconjugated
0.05mg 1mg/ml  $425.00
Anti-RRM2B / p53R2 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Anti-RRM2B / p53R2 antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.

RRM2B / P53R2 Antibody (N-Terminus) LS-C154254
Publications (3)
Publications (3)
Rabbit Polyclonal (IgG) to Human RRM2B / P53R2
Human
ELISA IF IHC IP WB
Unconjugated
100µg 0.82mg/ml  $425.00
Anti-RRM2B antibody - Western Blot. Western blot of affinity purified anti-RRM2B antibody shows detection of recombinant (lanes 1 and 3) and endogenous protein (lanes 1 to 4) in whole cell extracts from transfected 293T. Lane 1 contains purified recombinant human p53R2. Lane 2 contains 293T cells transfected with control vector. Lane 3 contains 293T transfected with p53R2-myc. Lane 4:293T transfected with ScRNA. Lane 5:293T transfected with p53R2 SiRNA The band at 40.7 kD, indicated by the bottom arrowhead, corresponds to the expected molecular weight of endogenous RRM2B. The band with the middle arrow corresponds to myc-tagged p53R2 at 41.9kD. The highest band at 44.3 kD corresponds to recombinant p53R2. Primary antibody was diluted to 1 ug/mL and incubated overnight at 4C. ECL detection was used.

RRM2B / P53R2 Antibody (aa318-332) LS-C313179
Rabbit Polyclonal to Human RRM2B / P53R2
Xenopus, Chicken, Sheep, Bovine, Rabbit, Mouse, Rat, Pig, Horse, Bat, Human, Monkey
WB
Unconjugated
100µg 200µl 0.5mg/ml  $305.00
WB of RRM2B antibody. Lane 1: Rat Thymus Tissue Lysate. Lane 2: MCF-7 Cell Lysate. Lane 3: A431 Cell Lysate. Lane 4: HELA Cell Lysate..

RRM2B / P53R2 Antibody LS-C489005
Rabbit Polyclonal to Human RRM2B / P53R2
Human
ELISA IHC IHC-P WB
Unconjugated
50µl  $255.00; 100µl  $305.00; 200µl  $355.00

RRM2B / P53R2 Antibody (aa1-351) LS-C377858
Rabbit Polyclonal (IgG) to Human RRM2B / P53R2
Human
ELISA IHC IHC-P WB
Unconjugated
50µl  $285.00; 100µl  $385.00
Immunohistochemistry of paraffin-embedded human lung using antibody at 1:100 dilution.
Western blot. All lanes: E3 Ribonucleoside-diphosphate reductase subunit M2 B antibody at 6 ug/ml. Lane 1: MCF-7 whole cell lysate. Lane 2: HeLa whole cell lysate. Lane 3: HepG2 whole cell lysate. secondary Goat polyclonal to rabbit at 1:10000 dilution. Predicted band size: 41 kDa. Observed band size: 41 kDa.

RRM2B / P53R2 Antibody (aa1-351) LS-C377857
Rabbit Polyclonal (IgG) to Human RRM2B / P53R2
Human
ELISA IHC IHC-P WB
Unconjugated
50µl  $285.00; 100µl  $385.00
Immunohistochemistry of paraffin-embedded human tonsil using antibody at 1:100 dilution.
Western blot. All lanes: E3 Ribonucleoside-diphosphate reductase subunit M2 B antibody at 3 ug/ml. Lane 1: MCF-7 whole cell lysate. Lane 2: HeLa whole cell lysate. Lane 3: HepG2 whole cell lysate. secondary Goat polyclonal to rabbit at 1:10000 dilution. Predicted band size: 41 kDa. Observed band size: 41 kDa.

RRM2B / P53R2 Antibody LS-C409562
Rabbit Polyclonal (IgG) to Human RRM2B / P53R2
Mouse, Rat, Human
IF WB
Unconjugated
50µl  $255.00; 100µl  $315.00; 200µl  $425.00
Immunofluorescence analysis of A549 cells.

RRM2B / P53R2 Antibody LS-C489007
Mouse Monoclonal to Human RRM2B / P53R2
Human
ELISA WB
Unconjugated
50µl  $255.00; 100µl  $305.00; 200µl  $355.00; 1ml  $1,335.00

RRM2B / P53R2 Antibody LS-C489006
Rabbit Polyclonal to Human RRM2B / P53R2
Human
IHC IHC-P
Unconjugated
50µl  $275.00; 100µl  $355.00

RRM2B / P53R2 Antibody (aa128-157) LS-C324839
Rabbit Polyclonal (IgG) to Human RRM2B / P53R2
Human
ELISA WB
Unconjugated
200µl  $590.00

RRM2B / P53R2 Antibody (aa128-157, Biotin) LS-C268617
Rabbit Polyclonal (IgG) to Human RRM2B / P53R2
Human
ELISA WB
Biotin Conjugated
200µl  $740.00

RRM2B / P53R2 Antibody (aa128-157, FITC) LS-C268618
Rabbit Polyclonal (IgG) to Human RRM2B / P53R2
Human
ELISA WB
FITC Conjugated
200µl  $740.00

RRM2B / P53R2 Antibody (aa128-157, AP) LS-C268615
Rabbit Polyclonal (IgG) to Human RRM2B / P53R2
Human
ELISA WB
AP Conjugated
200µl  $740.00

RRM2B / P53R2 Antibody (aa128-157, APC) LS-C268616
Rabbit Polyclonal (IgG) to Human RRM2B / P53R2
Human
ELISA WB
APC Conjugated
200µl  $740.00

RRM2B / P53R2 Antibody (aa128-157, Azide-free, HRP) LS-C268619
Rabbit Polyclonal (IgG) to Human RRM2B / P53R2
Human
ELISA WB
HRP Conjugated, Azide-free
200µl  $740.00

RRM2B / P53R2 Antibody (aa128-157, PE) LS-C268622
Rabbit Polyclonal (IgG) to Human RRM2B / P53R2
Human
ELISA WB
PE Conjugated
200µl  $740.00

RRM2B / P53R2 Antibody (Internal) LS-C385311
Rabbit Polyclonal (IgG) to Human RRM2B / P53R2
Mouse, Rat, Human
ELISA WB
Unconjugated
100µl 1mg/ml  $265.00
Western blot of p53R2 antibody

RRM2B / P53R2 Antibody LS-C745340
Rabbit Polyclonal (IgG) to Human RRM2B / P53R2
Human
ELISA WB
Unconjugated
25µl 0.82mg/ml  $235.00
Western blot using the affinity purified anti-RRM2B antibody shows detection of recombinant (lanes 1 and 3) and endogenous protein (lanes 1 to 4) in whole cell extracts from transfected 293T. Lane 1 contains purified recombinant human p53R2. Lane 2 contains 293T cells transfected with control vector. Lane 3 contains 293T transfected with p53R2-myc. Lane 4: 293T transfected with ScRNA. Lane 5: 293T tranfected with p53R2 SiRNA The band at 40.7 kDa, indicated by the bottom arrowhead, corresponds to the expected molecular weight of endogenous RRM2B. The band with the middle arrow corresponds to myc-tagged p53R2 at 41.9kDa. The highest band at 44.3 kDa corresponds to recombinant p53R2. Primary antibody was diluted to 1µg/mL and incubated overnight at 4°C. ECL detection was used.

RRM2B / P53R2 Antibody LS-C489003
Rabbit Polyclonal to Human RRM2B / P53R2
Human
ELISA
Unconjugated
50µl  $275.00; 100µl  $355.00

RRM2B / P53R2 Antibody LS-C489004
Rabbit Polyclonal to Human RRM2B / P53R2
Human
ELISA
Unconjugated
100µl  $255.00; 200µl  $305.00; 400µl  $355.00

RRM2B / P53R2 Antibody (aa2-17) LS-C153107
Rabbit Polyclonal (IgG) to Human RRM2B / P53R2
Mouse, Rat, Human
WB
Unconjugated
100µg  $415.00

RRM2B / P53R2 Antibody LS-C489002
Rabbit Polyclonal to Human RRM2B / P53R2
Human
WB
Unconjugated
50µl  $275.00; 100µl  $355.00

RRM2B / P53R2 Antibody (Internal) LS-C358853
Rabbit Polyclonal to Human RRM2B / P53R2
Mouse, Rat, Human, Monkey
WB
Unconjugated
30µl 1mg/ml  $205.00; 100µl 1mg/ml  $245.00; 200µl 1mg/ml  $305.00
Western blot analysis of RRM2B expression in HepG2 (A); MCF7 (B) whole cell lysates.

RRM2B / P53R2 Antibody (aa128-157) LS-C162769
Rabbit Polyclonal to Human RRM2B / P53R2
Human
WB
Unconjugated
400µl  $325.00
RRM2B Antibody western blot of HepG2 cell line lysates (35 ug/lane). The RRM2B antibody detected the RRM2B protein (arrow).

RRM2B / P53R2 Antibody (aa81-130) LS-C201502
Rabbit Polyclonal to Human RRM2B / P53R2
Xenopus, Bat, Rat, Rabbit, Mouse, Bovine, Human
WB
Unconjugated
100µl 0.5mg/ml  $365.00
Western blot of Human 293T. RRM2B antibody dilution 1.0 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Showing 1-25 of 29 results

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For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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