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RPSA / Laminin Receptor

ribosomal protein SA

Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Many of the effects of laminin are mediated through interactions with cell surface receptors. These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins. This gene encodes a high-affinity, non-integrin family, laminin receptor 1. This receptor has been variously called 67 kD laminin receptor, 37 kD laminin receptor precursor (37LRP) and p40 ribosome-associated protein. The amino acid sequence of laminin receptor 1 is highly conserved through evolution, suggesting a key biological function. It has been observed that the level of the laminin receptor transcript is higher in colon carcinoma tissue and lung cancer cell line than their normal counterparts. Also, there is a correlation between the upregulation of this polypeptide in cancer cells and their invasive and metastatic phenotype. Multiple copies of this gene exist, however, most of them are pseudogenes thought to have arisen from retropositional events. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.

Gene Name: ribosomal protein SA
Family/Subfamily: Laminin , not assigned-Laminin
Synonyms: RPSA, 37 kDa laminin receptor, 37LRP, 40S ribosomal protein SA, 67LR, 67 kDa laminin receptor, 37/67 kDa laminin receptor, 67kD, ribosomal protein SA, LAMR1, LAMBR, Laminin receptor 1, LamR, NEM/1CHD4, SA, LRP/LR, Laminin binding protein, Laminin Receptor, LRP, p40, Ribosomal protein SA
Target Sequences: NM_002295 NP_002286.2 P08865

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Products
Proteins (12)
Over-Expression Lysate (4)
Recombinant (8)
RPSA / Laminin Receptor (12)
No (12)
10His, N-terminus + Myc, C-terminus (1)
6His, N-terminus (2)
GST (1)
GST, N-terminus (1)
MBP, N-terminus + 6His, C-terminus (1)
Myc-DDK (Flag) (6)
Human (10)
293T Cells (2)
Baculovirus (1)
E. coli (2)
HEK 293 Cells (4)
Wheat Germ Extract (2)
Yeast (1)
Purified (4)
RPSA / Laminin Receptor Protein - SDS-PAGE under reducing conditions and visualized by Coomassie blue staining
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E. coli
6His, N-terminus
35 kDa
10 µg/$265; 50 µg/$315; 100 µg/$365
RPSA / Laminin Receptor Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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Yeast
6His, N-terminus
34.6 kDa
100 µg/$570; 20 µg/$395; 1 mg/$1,973
RPSA / Laminin Receptor Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
RPSA / Laminin Receptor Protein - Purified recombinant protein RPSA was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
32.7 kDa
20 µg/$1,107
RPSA / Laminin Receptor Protein - Purified recombinant protein RPSA was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
32.7 kDa
20 µg/$1,107
RPSA / Laminin Receptor Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
32.7 kDa
20 µg/$150
RPSA / Laminin Receptor Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
32.7 kDa
20 µg/$150
RPSA / Laminin Receptor Protein - 12.5% SDS-PAGE of human RPSA stained with Coomassie Blue
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Wheat Germ Extract
GST
58.19 kDa
10 µg/$479; 25 µg/$670
RPSA / Laminin Receptor Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
32.7 kDa
100 µg/$494
RPSA / Laminin Receptor Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
Baculovirus
MBP, N-terminus + 6His, C-terminus
76.7 kDa
100 µg/$1,164; 20 µg/$475; 1 mg/$2,187
RPSA / Laminin Receptor Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
E. coli
10His, N-terminus + Myc, C-terminus
37.7 kDa
1 mg/$1,679; 100 µg/$500; 20 µg/$364
RPSA / Laminin Receptor Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
32.7 kDa
100 µg/$494
Viewing 1-12 of 12 product results


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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).