RPS6KA4 / MSK2 / RSK-B

ribosomal protein S6 kinase, 90kDa, polypeptide 4

Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factor RELA, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines. Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors.

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Proteins (6)

Type

Over-Expression Lysate (4)

Recombinant (2)

Target

RPS6KA4 / MSK2 / RSK-B (6)

Publications

No (6)

Tag

GST (1)

Myc-DDK (Flag) (5)

Species

Human (4)

Source

293T Cells (2)

HEK 293 Cells (3)

Wheat Germ Extract (1)

Purification

Purified (1)

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Human RPS6KA4 / MSK2 / RSK-B Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G68892

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

85.4 kDa

Price:

20 µg/$1,107

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Human RPS6KA4 / MSK2 / RSK-B Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G83327

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

84.7 kDa

Price:

20 µg/$215

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Human RPS6KA4 / MSK2 / RSK-B Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G83328

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

85.4 kDa

Price:

20 µg/$215

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Human RPS6KA4 / MSK2 / RSK-B Protein (Recombinant GST) (Full Length) - LS-G31420

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

84.5 kDa

Price:

2 µg/$439

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RPS6KA4 / MSK2 / RSK-B Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G116993

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

85.4 kDa

Price:

100 µg/$710

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RPS6KA4 / MSK2 / RSK-B Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G122058

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

84.7 kDa

Price:

100 µg/$710

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