RPS6KA1 / RSK1

ribosomal protein S6 kinase, 90kDa, polypeptide 1

Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1. In fibroblast, is required for EGF-stimulated phosphorylation of CREB1, which results in the subsequent transcriptional activation of several immediate-early genes. In response to mitogenic stimulation (EGF and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP. Upon insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at 'Ser-9' and inhibiting its activity. Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent mechanism and promotes translation initiation by facilitating assembly of the preinitiation complex. In response to insulin, phosphorylates EIF4B, enhancing EIF4B affinity for the EIF3 complex and stimulating cap-dependent translation. Is involved in the mTOR nutrient-sensing pathway by directly phosphorylating TSC2 at 'Ser-1798', which potently inhibits TSC2 ability to suppress mTOR signaling, and mediates phosphorylation of RPTOR, which regulates mTORC1 activity and may promote rapamycin-sensitive signaling independently of the PI3K/AKT pathway. Mediates cell survival by phosphorylating the pro-apoptotic proteins BAD and DAPK1 and suppressing their pro-apoptotic function. Promotes the survival of hepatic stellate cells by phosphorylating CEBPB in response to the hepatotoxin carbon tetrachloride (CCl4). Is involved in cell cycle regulation by phosphorylating the CDK inhibitor CDKN1B, which promotes CDKN1B association with 14-3-3 proteins and prevents its translocation to the nucleus and inhibition of G1 progression.

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Proteins (5)

Type

Over-Expression Lysate (2)

Recombinant (3)

Target

RPS6KA1 / RSK1 (5)

Publications

No (5)

Tag

GST (1)

His-S (1)

Myc-DDK (Flag) (3)

Species

Human (4)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Purification

Purified (1)

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Human RPS6KA1 / RSK1 Protein (Recombinant His-S) (aa62-321) - LS-G26168

Source:

E. coli

Tag:

His-S

Molecular Weight:

33.5 kDa

Price:

10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119

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Human RPS6KA1 / RSK1 Protein (Recombinant GST) (Full Length) - LS-G30257

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

106.2599 kDa

Price:

10 µg/$479; 25 µg/$670

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Human RPS6KA1 / RSK1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G66894

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

82.5 kDa

Price:

20 µg/$1,107

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Human RPS6KA1 / RSK1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G78668

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

82.5 kDa

Price:

20 µg/$150

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RPS6KA1 / RSK1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99918

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

82.5 kDa

Price:

100 µg/$494

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