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RPS3 / Ribosomal Protein S3

ribosomal protein S3

Involved in translation as a component of the 40S small ribosomal subunit (PubMed:8706699). Has endonuclease activity and plays a role in repair of damaged DNA (PubMed:7775413). Cleaves phosphodiester bonds of DNAs containing altered bases with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA (PubMed:15707971). Displays high binding affinity for 7,8-dihydro-8-oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species (ROS) (PubMed:14706345). Has also been shown to bind with similar affinity to intact and damaged DNA (PubMed:18610840). Stimulates the N-glycosylase activity of the base excision protein OGG1 (PubMed:15518571). Enhances the uracil excision activity of UNG1 (PubMed:18973764). Also stimulates the cleavage of the phosphodiester backbone by APEX1 (PubMed:18973764). When located in the mitochondrion, reduces cellular ROS levels and mitochondrial DNA damage (PubMed:23911537). Has also been shown to negatively regulate DNA repair in cells exposed to hydrogen peroxide (PubMed:17049931). Plays a role in regulating transcription as part of the NF-kappa-B p65-p50 complex where it binds to the RELA/p65 subunit, enhances binding of the complex to DNA and promotes transcription of target genes (PubMed:18045535). Represses its own translation by binding to its cognate mRNA (PubMed:20217897). Binds to and protects TP53/p53 from MDM2-mediated ubiquitination (PubMed:19656744). Involved in spindle formation and chromosome movement during mitosis by regulating microtubule polymerization (PubMed:23131551). Involved in induction of apoptosis through its role in activation of CASP8 (PubMed:14988002). Induces neuronal apoptosis by interacting with the E2F1 transcription factor and acting synergistically with it to up-regulate pro-apoptotic proteins BCL2L11/BIM and HRK/Dp5 (PubMed:20605787). Interacts with TRADD following exposure to UV radiation and induces apoptosis by caspase-dependent JNK activation (PubMed:22510408).

Gene Name: ribosomal protein S3
Synonyms: RPS3, 40S ribosomal protein S3, IMR-90 ribosomal protein S3, S3, Ribosomal protein S3
Target Sequences: NM_001005 NP_000996.2 P23396

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Products
Antibodies (35)
Primary (35)
RPS3 / Ribosomal Protein S3 (35)
Human (35)
Mouse (25)
Rat (23)
Bovine (9)
Chicken (1)
Dog (9)
Guinea pig (8)
Horse (8)
Monkey (4)
Orangutan (3)
Pig (5)
Rabbit (8)
Xenopus (3)
Zebrafish (5)
IHC (15)
IHC-P (6)
WB (35)
ELISA (10)
ICC (3)
IF (8)
IP (5)
Peptide-ELISA (2)
rabbit (32)
mouse (3)
Product Group
IHCPlus (4)
IgG (17)
IgG1 (1)
IgG1,k (1)
IgG2a,k (1)
monoclonal mc (4)
polyclonal pc (31)
2A8 (1)
RP159-1 (1)
Biotin Conjugated (2)
FITC Conjugated (2)
HRP Conjugated (2)
Unconjugated (29)
C-Terminus (5)
aa116-165 (4)
140-220 aa, C-terminal (1)
aa1-50 (1)
aa160-209 (1)
aa171-220 (1)
aa193-243 (1)
No (35)
RPS3 / Ribosomal Protein S3 Antibody - Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)
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RPS3 / Ribosomal Protein S3 Rabbit anti-Human Polyclonal (aa193-243) Antibody
Human
IHC, IHC-P, IP, WB
Unconjugated
50 µl/$485
RPS3 / Ribosomal Protein S3 Antibody - Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
RPS3 / Ribosomal Protein S3 Mouse anti-Human Monoclonal (RP159-1) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$440
RPS3 / Ribosomal Protein S3 Antibody - Immunohistochemistry of paraffin-embedded mouse lung using RPS3 antibodyat dilution of 1:100 (40x lens).
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RPS3 / Ribosomal Protein S3 Rabbit anti-Human Monoclonal Antibody
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
50 µl/$306; 100 µl/$381; 200 µl/$489
RPS3 / Ribosomal Protein S3 Antibody - RPS3 monoclonal antibody (M03), clone 2A8. Western Blot analysis of RPS3 expression in HeLa NE.
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RPS3 / Ribosomal Protein S3 Mouse anti-Human Monoclonal (2A8) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$413
RPS3 / Ribosomal Protein S3 Antibody - Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
RPS3 / Ribosomal Protein S3 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, ICC, IHC, IHC-P, IP, WB
Unconjugated
50 µg/$460
RPS3 / Ribosomal Protein S3 Antibody - S3 / RPS3 antibody Western Blot of A549.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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RPS3 / Ribosomal Protein S3 Rabbit anti-Human Polyclonal (aa116-165) Antibody
Xenopus, Zebrafish, Horse, Rat, Rabbit, Mouse, Dog, Guinea pig, Bovine, Human
WB
Unconjugated
100 µl/$414
Select
RPS3 / Ribosomal Protein S3 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ICC, IF, WB
Unconjugated
100 µl/$580
RPS3 / Ribosomal Protein S3 Antibody - Immunofluorescence analysis of HeLa cells.
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RPS3 / Ribosomal Protein S3 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
20 µl/$253; 50 µl/$279; 100 µl/$333; 200 µl/$429
RPS3 / Ribosomal Protein S3 Antibody - 1:100 staining human breast carcinoma tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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RPS3 / Ribosomal Protein S3 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100 µl/$369; 200 µl/$411
RPS3 / Ribosomal Protein S3 Antibody - Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
RPS3 / Ribosomal Protein S3 Rabbit anti-Human Polyclonal (aa1-50) Antibody
Human
IHC, IHC-P, IP, WB
Unconjugated
50 µl/$485
Select
RPS3 / Ribosomal Protein S3 Rabbit anti-Human Polyclonal Antibody
Human
ICC, IF, IP, WB
Unconjugated
50 µl/$275; 100 µl/$312; 200 µl/$350
RPS3 / Ribosomal Protein S3 Antibody - Immunohistochemistry analysis of paraffin-embedded human tonsil tissue, using RPS3 Antibody. The picture on the right is blocked with the synthesized peptide.
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RPS3 / Ribosomal Protein S3 Rabbit anti-Human Polyclonal (aa171-220) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$318; 100 µl/$378
Select
RPS3 / Ribosomal Protein S3 Mouse anti-Human Monoclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$361
Select
RPS3 / Ribosomal Protein S3 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
20 µl/$242; 60 µl/$284; 120 µl/$343; 200 µl/$451
Select
RPS3 / Ribosomal Protein S3 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$331
Select
RPS3 / Ribosomal Protein S3 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$331
RPS3 / Ribosomal Protein S3 Antibody - Western blot of Ribosomal Protein S3 antibody
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RPS3 / Ribosomal Protein S3 Rabbit anti-Human Polyclonal (140-220 aa, C-terminal) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50 µl/$279; 100 µl/$309; 200 µl/$379
RPS3 / Ribosomal Protein S3 Antibody - Peptide - + Immunohistochemistry analysis of paraffin-embedded human tonsil tissue using RPS3 antibody.
Select
RPS3 / Ribosomal Protein S3 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
100 µg/$347
RPS3 / Ribosomal Protein S3 Antibody - Western blot analysis of the lysates from RAW264.7cells using RPS3 antibody.
Select
RPS3 / Ribosomal Protein S3 Rabbit anti-Human Polyclonal (aa160-209) Antibody
Mouse, Rat, Human
IHC, Peptide-ELISA, WB
Unconjugated
50 µl/$318; 100 µl/$378
RPS3 / Ribosomal Protein S3 Antibody - IHC analysis of RPS3 using anti-RPS3 antibody. RPS3 was detected in paraffin-embedded section of human tonsil tissues. Heat mediated antigen retrieval was performed in citrate buffer (pH6, epitope retrieval solution) for 20 mins. The tissue section was blocked with 10% goat serum. The tissue section was then incubated with 1µg/ml rabbit anti-RPS3 Antibody overnight at 4°C. Biotinylated goat anti-rabbit IgG was used as secondary antibody and incubated for 30 minutes at 37°C. The tissue section was developed using Strepavidin-Biotin-Complex (SABC) with DAB as the chromogen.
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RPS3 / Ribosomal Protein S3 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC-P, WB
Unconjugated
100 µg/$421
Select
RPS3 / Ribosomal Protein S3 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, WB
Unconjugated
100 µl/$433
Select
RPS3 / Ribosomal Protein S3 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, WB
Unconjugated
60 µl/$280; 120 µl/$343; 200 µl/$451
RPS3 / Ribosomal Protein S3 Antibody - Immunofluorescence analysis of HeLa cells using RPS3 antibody. Blue: DAPI for nuclear staining.
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RPS3 / Ribosomal Protein S3 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, WB
Unconjugated
20 µl/$253; 50 µl/$279; 100 µl/$333; 200 µl/$429
Select
RPS3 / Ribosomal Protein S3 Rabbit anti-Human Polyclonal Antibody
Human
IP, WB
Unconjugated
50 µl/$275; 100 µl/$312; 200 µl/$350
Select
RPS3 / Ribosomal Protein S3 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
60 µl/$280; 120 µl/$343; 200 µl/$451
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).