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RPRD1B
Regulation of nuclear pre-mRNA domain containing 1B
Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD. Transcriptional regulator which enhances expression of CCND1. Promotes binding of RNA polymerase II to the CCDN1 promoter and to the termination region before the poly-A site but decreases its binding after the poly-A site. Prevents RNA polymerase II from reading through the 3' end termination site and may allow it to be recruited back to the promoter through promotion of the formation of a chromatin loop. Also enhances the transcription of a number of other cell cycle-related genes including CDK2, CDK4, CDK6 and cyclin-E but not CDKN1A, CDKN1B or cyclin-A. Promotes cell proliferation.
| Gene Name: | Regulation of nuclear pre-mRNA domain containing 1B |
| Synonyms: | RPRD1B, CREPT, DJ1057B20.2, NET60, C20orf77 |
| Target Sequences: | NM_021215 NP_067038.1 Q9NQG5 |
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