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RPL10 / Ribosomal Protein L10

ribosomal protein L10

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of four RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L10E family of ribosomal proteins. It is located in the cytoplasm. In vitro studies have shown that the chicken protein can bind to c-Jun and can repress c-Jun-mediated transcriptional activation, but these activities have not been demonstrated in vivo. This gene was initially identified as a candidate for a Wilms tumor suppressor gene, but later studies determined that this gene is not involved in the suppression of Wilms tumor. This gene has been referred to as 'laminin receptor homolog' because a chimeric transcript consisting of sequence from this gene and sequence from the laminin receptor gene was isolated; however, it is not believed that this gene encodes a laminin receptor. Alternative splicing results in multiple transcript variants. This gene also uses multiple polyA signals, with the 3'-most polyA signal overlapping the deoxyribonuclease I-like 1 gene on the opposite strand. This gene is co-transcribed with the small nucleolar RNA gene U70, which is located in its fifth intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.

Gene Name: ribosomal protein L10
Synonyms: RPL10, 60S ribosomal protein L10, AUTSX5, DXS648E, Protein QM, L10, Wilms tumor-related protein, Tumor suppressor QM, Ribosomal protein L10, DXS648, Laminin receptor homolog, QM
Target Sequences: NM_006013 NP_006004.3 P27635

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Proteins (6)
Over-Expression Lysate (2)
Recombinant (4)
RPL10 / Ribosomal Protein L10 (6)
No (6)
6His, N-terminus (1)
GST (2)
GST, N-terminus (1)
Myc-DDK (Flag) (2)
Fruit fly (1)
Human (4)
293T Cells (1)
E. coli (1)
HEK 293 Cells (1)
Wheat Germ Extract (3)
Purified (3)
RPL10 / Ribosomal Protein L10 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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E. coli
6His, N-terminus
29.5 kDa
20 µg/$405; 1 mg/$1,679; 100 µg/$598
RPL10 / Ribosomal Protein L10 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
2 µg/$439
RPL10 / Ribosomal Protein L10 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
24.4 kDa
100 µg/$494
RPL10 / Ribosomal Protein L10 Protein - 12.5% SDS-PAGE of human RPL10 stained with Coomassie Blue
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Wheat Germ Extract
GST
51 kDa
2 µg/$439
RPL10 / Ribosomal Protein L10 Protein - 12.5% SDS-PAGE of human RPL10 stained with Coomassie Blue
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Wheat Germ Extract
GST
49.28 kDa
2 µg/$439
RPL10 / Ribosomal Protein L10 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
24.4 kDa
20 µg/$150
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).