RPA3

replication protein A3, 14kDa

As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage (PubMed:9430682). In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin, in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair (PubMed:7697716). Plays also a role in base excision repair (BER), probably through interaction with UNG (PubMed:9765279). Through RFWD3 may activate CHEK1 and play a role in replication checkpoint control. Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance. RPA3 has its own single-stranded DNA-binding activity and may be responsible for polarity of the binding of the complex to DNA (PubMed:19010961). As part of the alternative replication protein A complex, aRPA, binds single-stranded DNA and probably plays a role in DNA repair. Compared to the RPA2-containing, canonical RPA complex, may not support chromosomal DNA replication and cell cycle progression through S-phase. The aRPA may not promote efficient priming by DNA polymerase alpha but could support DNA polymerase delta synthesis in the presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange (PubMed:19996105).

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Products

Antibodies (21)

Proteins (4)

Type

Over-Expression Lysate (2)

Primary (21)

Recombinant (2)

Target

RPA3 (25)

Reactivity

Human (21)

Mouse (9)

Rat (4)

Application

IHC (7)

IHC-P (3)

WB (20)

ELISA (12)

IF (1)

IP (3)

Peptide-ELISA (1)

RNAi (1)

Host

rabbit (17)

mouse (4)

Product Group

IHCPlus (1)

Isotype

IgG (16)

IgG1 (2)

IgG1,k (1)

IgG1,l (1)

Clonality

monoclonal mc (4)

polyclonal pc (17)

Clone

111 (1)

14.2 (1)

1F4 (1)

Format

Biotin Conjugated (2)

FITC Conjugated (2)

HRP Conjugated (2)

Preservative Free (1)

Unconjugated (15)

Epitope

N-Terminus (1)

aa1-121 (1)

Publications

No (25)

Tag

GST (1)

GST, N-terminus (1)

Myc-DDK (Flag) (2)

Species

Human (3)

Source

293T Cells (1)

HEK 293 Cells (1)

Wheat Germ Extract (2)

Purification

Purified (1)

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RPA3 Antibody LS-C409021

Antibody:

RPA3 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

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IHC-plus™ RPA3 Antibody (clone 111) LS-B1711

(4.0) Rating

Antibody:

RPA3 Mouse anti-Human Monoclonal (111) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, IHC-P, IP, WB

Format:

Unconjugated

Price:

50 µl/$460

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RPA3 Antibody (clone 14.2, Preservative Free) LS-C20047

Antibody:

RPA3 Mouse anti-Human Monoclonal (Preservative Free) (14.2) Antibody

Reactivity:

Mouse, Human

Applications:

IP, WB

Format:

Unconjugated, Preservative Free

Price:

100 µl/$450

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RPA3 Antibody (clone 1F4) LS-C133091

Antibody:

RPA3 Mouse anti-Human Monoclonal (1F4) Antibody

Reactivity:

Human

Applications:

ELISA, RNAi, WB

Format:

Unconjugated

Price:

100 µg/$423

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RPA3 Antibody LS-C285756

Antibody:

RPA3 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

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RPA3 Antibody (HRP) LS-C317210

Antibody:

RPA3 Rabbit anti-Human Polyclonal (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

HRP Conjugated

Price:

50 µg/$294; 100 µg/$360

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RPA3 Antibody (Biotin) LS-C317213

Antibody:

RPA3 Rabbit anti-Human Polyclonal (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Biotin Conjugated

Price:

50 µg/$294; 100 µg/$360

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RPA3 Antibody (FITC) LS-C318837

Antibody:

RPA3 Rabbit anti-Human Polyclonal (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

FITC Conjugated

Price:

50 µg/$294; 100 µg/$360

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

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RPA3 Antibody (aa1-121) LS-C185337

Antibody:

RPA3 Rabbit anti-Human Polyclonal (aa1-121) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$450

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RPA3 Antibody LS-C749072

Antibody:

RPA3 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

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RPA3 Antibody LS-C780277

Antibody:

RPA3 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$357

Select

RPA3 Antibody LS-C820533

Antibody:

RPA3 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$412

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RPA3 Antibody (N-Terminus) LS-C83538

Antibody:

RPA3 Mouse anti-Human Monoclonal (N-Terminus) Antibody

Reactivity:

Mouse, Human

Applications:

IP, WB

Format:

Unconjugated

Price:

100 µg/$563

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RPA3 Antibody LS-C211480

Antibody:

RPA3 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

Select

RPA3 Antibody (HRP) LS-C211482

Antibody:

RPA3 Rabbit anti-Human Polyclonal (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

HRP Conjugated

Price:

50 µg/$294; 100 µg/$360

Select

RPA3 Antibody (Biotin) LS-C211487

Antibody:

RPA3 Rabbit anti-Human Polyclonal (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Biotin Conjugated

Price:

50 µg/$294; 100 µg/$360

Select

RPA3 Antibody (FITC) LS-C211486

Antibody:

RPA3 Rabbit anti-Human Polyclonal (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

FITC Conjugated

Price:

50 µg/$294; 100 µg/$360

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

Select

RPA3 Antibody LS-C813931

Antibody:

RPA3 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

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RPA3 Antibody LS-C803692

Antibody:

RPA3 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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RPA3 Antibody LS-C752795

Antibody:

RPA3 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA

Format:

Unconjugated

Price:

100 µg/$351

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RPA3 Antibody LS-C770320

Antibody:

RPA3 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

WB

Format:

Unconjugated

Price:

60 µl/$331; 120 µl/$403; 200 µl/$529

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Human RPA3 Protein (Recombinant GST, N-terminus) (aa12-121) - LS-G59939

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human RPA3 Protein (Recombinant GST) (Full Length) - LS-G30197

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

40 kDa

Price:

10 µg/$479; 25 µg/$670

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RPA3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99915

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

13.4 kDa

Price:

100 µg/$494

Select

Human RPA3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G78607

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

13.4 kDa

Price:

20 µg/$150

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