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RPA2 / RFA2 / RPA34

replication protein A2, 32kDa

As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair. Plays also a role in base excision repair (BER) probably through interaction with UNG. Through RFWD3 may activate CHEK1 and play a role in replication checkpoint control. Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance.

Gene Name: replication protein A2, 32kDa
Synonyms: RPA2, RF-A protein 2, RP-A p34, RPA34, Replication protein A2, 32kDa, RP-A p32, REPA2, Replication factor A protein 2, Replication protein A2 (32kD), RPA32
Target Sequences: NM_002946 NP_002937.1 P15927

Publications (3)

1
Pre-exposure to ionizing radiation stimulates DNA double strand break end resection, promoting the use of homologous recombination repair. Nakajima NI, Hagiwara Y, Oike T, Okayasu R, Murakami T, Nakano T, Shibata A. PloS one. 2015 10:e0122582. (WB, IF; Human) [Full Text Article] [PubMed:25826455] [PMC:PMC4380452] Related Antibodies: LS-C38952.
2
DNA double-strand break repair pathway choice is directed by distinct MRE11 nuclease activities. Shibata A, Moiani D, Arvai AS, Perry J, Harding SM, Genois MM, Maity R, van Rossum-Fikkert S, Kertokalio A, Romoli F, Ismail A, Ismalaj E, Petricci E, Neale MJ, Bristow RG, Masson JY, Wyman C, Jeggo PA, Tainer JA. Molecular cell. Jan;53:7-18. [Full Text Article] [PubMed:24316220] [PMC:PMC3909494] Related Antibodies: LS-C38952.
3
Epigenetic changes in histone acetylation underpin resistance to the topoisomerase I inhibitor irinotecan. Meisenberg C, Ashour ME, El-Shafie L, Liao C, Hodgson A, Pilborough A, Khurram SA, Downs JA, Ward SE, El-Khamisy SF. Nucleic acids research. 2017 45:1159-1176. (WB; Human) [Full Text Article] [PubMed:28180300] [PMC:PMC5388393] Related Antibodies: LS-C38952.

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RPA2 / RFA2 / RPA34 (5)
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RPA2 / RFA2 / RPA34 Protein
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E. coli
His
50 µg/$392; 250 µg/$872; 10 µg/$286; 20 µg/$348; 100 µg/$511; 500 µg/$1,355
RPA2 / RFA2 / RPA34 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
29.1 kDa
100 µg/$494
RPA2 / RFA2 / RPA34 Protein - 12.5% SDS-PAGE of human RPA2 stained with Coomassie Blue
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Wheat Germ Extract
GST
55.44 kDa
10 µg/$479; 25 µg/$670
RPA2 / RFA2 / RPA34 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
29.1 kDa
20 µg/$150
RPA2 / RFA2 / RPA34 Protein - Purified recombinant protein RPA2 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
29.1 kDa
20 µg/$1,107
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).