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Shirley, MA 01464
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ROS1 / ROS
c-ros oncogene 1 , receptor tyrosine kinase
Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation of VAV3, a guanine nucleotide exchange factor regulating cell morphology. May activate other downstream signaling proteins including AKT1, MAPK1, MAPK3, IRS1 and PLCG2.
| Gene Name: | c-ros oncogene 1 , receptor tyrosine kinase |
| Family/Subfamily: | Protein Kinase , Ros/Sevenless |
| Synonyms: | ROS1, C-ros-1, c-ros, C-Ros receptor tyrosine kinase, MCF3, Proto-oncogene c-Ros, Proto-oncogene c-Ros-1, ROS |
| Target Sequences: | NM_002944 NP_002935.2 P08922 |
Publications (2)
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